The National Centre for Cell Science (NCCS), an autonomous organisation aided by the Department of Biotechnology, Government of India, was established to facilitate cell biology research in the country.https://nccs.res.inen-usCopyright © 2026 National Center for Cell Science All rights reserved.‘Differentiation and functional plasticity of gamma-delta T cells under homeostatic and disease conditions’ Shilpi Giri and Girdhari Lal. Molecular Immunology 136 (2021) 138-149 https://nccs.res.in/research-highlights/32https://nccs.res.in/research-highlights/32Jan 03, 2022 12:00:00 AM GMT+5:30‘Regulatory B cells (Bregs) inhibit osteoclastogenesis and prevent bone loss in osteoporotic mice mode.’  - Sapra L, Bhardwaj A, Mishra PK, Verma BK, Mishra GC, Srivastava R K. Frontiers in Immunology-Inflammation - 30 June 2021 , https://doi.org/10.3389/fimmu.2021.691081. https://nccs.res.in/research-highlights/33https://nccs.res.in/research-highlights/33Jan 03, 2022 12:00:00 AM GMT+5:30‘From discovery to approval: A brief history of the  compstatin family of complement C3 inhibitors. ’ Mastellos DC, Ricklin D, Sfyroera G, Sahu A. Clinical Immunology https://nccs.res.in/research-highlights/34https://nccs.res.in/research-highlights/34Jan 03, 2022 12:00:00 AM GMT+5:30‘Structural biology of ionotropic glutamate delta receptors and their crosstalk with metabotropic glutamate receptors.’ Burada AP, Vinnakota R, Lambolez B, Tricoire L, Kumar J. Neuropharmacology.  https://nccs.res.in/research-highlights/35https://nccs.res.in/research-highlights/35Jan 03, 2022 12:00:00 AM GMT+5:30‘Antibiotic susceptibility of human gut-derived facultative anaerobic bacteria is different under aerobic versus anaerobic test conditions.’ - Microbes and Infection. Available online 8 June 2021, 104847. Kovale L, Nimonkar Y, Green SJ, Shouche YS, Om Prakash. https://nccs.res.in/research-highlights/37https://nccs.res.in/research-highlights/37Jan 03, 2022 12:00:00 AM GMT+5:30‘Extended Ecological Restoration of Bacterial Communities  in the Godavari River During the COVID-19 Lockdown Period: a Spatiotemporal Meta-analysis. ’ Jani K, Bandal J, Shouche Y, Shafi S, Azhar EI, Zumla A, Sharma A. ,  Microbial Ecology. 2021 Jul 5. doi: 10.1007/s00248-021-01781-0.. https://nccs.res.in/research-highlights/38https://nccs.res.in/research-highlights/38Jan 03, 2022 12:00:00 AM GMT+5:30‘Differential expression of complement receptors CR1/2 and CR4 by murine M1 and M2 macrophages. ’ Ghate A, Sharma S, Agrawa P, Sahu A. Molecular Immunology. Volume 137, September 2021, Pages 75-83.  https://nccs.res.in/research-highlights/39https://nccs.res.in/research-highlights/39Jan 03, 2022 12:00:00 AM GMT+5:30‘A novel nano-anti-malarial induces redox damage and elicits cytokine response to the parasite.’ Das S, Tripathy S, Pramanik P, Saha B, Roy S. Cytokine. 2021 Aug;144:155555. doi: 10.1016/j.cyto.2021.155555. https://nccs.res.in/research-highlights/40https://nccs.res.in/research-highlights/40Jan 03, 2022 12:00:00 AM GMT+5:30‘Resistin: A journey from metabolism to cancer.’ Ankita Deb , Bhavana Deshmukh , Pranay Ramteke , Firoz Khan Bhati , Manoj Kumar Bhat.  Translational Oncology. 2021, 14(10) : 101178 Available online 20 July 2021. https://nccs.res.in/research-highlights/41https://nccs.res.in/research-highlights/41Jan 03, 2022 12:00:00 AM GMT+5:30‘Neurokinin Receptors and their implications in Various autoimmune diseases’ Amrita Mishra and Girdhari Lal.  Current Research in Immunology 2 (2021) 66-78 1st July 2021. DOI: 10.1016/j.crimmu.2021.06.001 https://nccs.res.in/research-highlights/42https://nccs.res.in/research-highlights/42Jan 03, 2022 12:00:00 AM GMT+5:30Quantitative Insight into Immunopathology of SARS-CoV-2 Infection..... Bhavnita Soni, Ritika Kabra & Shailza Singh July 2021 DOI: 10.1089/jir.2020.0156 https://nccs.res.in/research-highlights/43https://nccs.res.in/research-highlights/43Jan 03, 2022 12:00:00 AM GMT+5:30DESC- ‘Exploring the neural mechanisms of aversion to bitter gourd phytochemicals in insects using Drosophila. ’ Chakraborty R, Thakur TS, Chauhan R , Manzar Z, Das G, Mitra A. Journal of Asia-Pacific Entomology. Available online 19 June 2021. https://nccs.res.in/research-highlights/44https://nccs.res.in/research-highlights/44Jan 02, 2022 12:00:00 AM GMT+5:30Behera S,  Reddy RR, Taunk K, Rapole S, Pharande RR, Suryawanshi AR Delineation of altered brain proteins associated with furious rabies virus infection in dogs by quantitative proteomics. Journal of Proteomics 2022;253;104463 https://nccs.res.in/research-highlights/52https://nccs.res.in/research-highlights/52Jan 12, 2022 12:00:00 AM GMT+5:30Taunk K,  Porto-Figueira P, Pereira AMJ,  Taware R, Luiza da Costa N, Barbosa R, Rapole S*, Camara JS Urinary Volatomic Expression Pattern: Paving the Way for. Identification of Potential Candidate Biosignatures for. Lung Cancer. Metabolites. 2022, 12(1), 36; https://doi.org/10.3390/metabo12010036   https://nccs.res.in/research-highlights/53https://nccs.res.in/research-highlights/53Jan 12, 2022 12:00:00 AM GMT+5:30STEM CELL RESEARCH ‘Generation of integration free hiPSCs clones, NSi001-A, NSi001- B, and NSi001-C from peripheral blood mononuclear cells of an individual with down syndrome having Robertsonian translocation. ’ SunitaNehra, Vishi Sharma, Mool Singh, Paresh Singhal,  Nishant Singhal Volume 61, May 2022, 102771 https://nccs.res.in/research-highlights/56https://nccs.res.in/research-highlights/56Apr 05, 2022 12:00:00 AM GMT+5:30The Protein Journal ‘Probing the interactions responsible for the structural  stability of Trypanothione reductase through Computer Simulation and Biophysical Characterization.’ Kumar A, Nimsarkar P, Singh S. The Protein Journal - April 2022   https://nccs.res.in/research-highlights/57https://nccs.res.in/research-highlights/57Apr 05, 2022 12:00:00 AM GMT+5:30Journal of Investigative Dermatology ‘+Vγ2+ γδ T cells in the presence of anti-CD40L control surgical inflammation and promote skin allograft survival. ’ Shilpi Giri, Heikrujam Thoihen Meitei , Amrita Mishra,  Girdhari Lal Journal of Investigative Dermatology -  Available online 2 April 2022 https://nccs.res.in/research-highlights/58https://nccs.res.in/research-highlights/58Apr 05, 2022 12:00:00 AM GMT+5:30CRISPR based therapeutics : a new paradigm in cancer................ Sumit Das, Shehnaz Bano, Prachi Kapse, Gopal C Kundu Molecular Cancer Volume 21, Article number : 85 (2022)   https://nccs.res.in/research-highlights/59https://nccs.res.in/research-highlights/59Apr 18, 2022 12:00:00 AM GMT+5:30‘Hydrogenophaga crocea sp. nov. associated with cyanobacterial mat isolated from farmland mud’ Thorat V, Tiwarekar B, Kirdat K, Chavan S, Markad S, Sathe S, Lodha T, Yadav A. https://nccs.res.in/research-highlights/60https://nccs.res.in/research-highlights/60Apr 20, 2022 12:00:00 AM GMT+5:30Deciphering miR-520c-3p as a probable target for immunometabolism in non-small cell lung cancer using systems biology approach.   Pooja Gulhane, Prajakta Nimsarkar, Komal Kharat, Shailza Singh. Oncotarget. 2022; 13:725-746. https://doi.org/10.18632/oncotarget.28233 https://nccs.res.in/research-highlights/61https://nccs.res.in/research-highlights/61May 01, 2022 12:00:00 AM GMT+5:30 Infection Dynamics of ATG8 in Leishmania: Balancing Autophagy for Therapeutic. Guhe V, Anjum F, Shafie A, Hassan MI, Rao Pasupuleti V, Singh S*. Molecules 2022, 27(10), 3142; https://doi.org/10.3390/molecules27103142. https://nccs.res.in/research-highlights/62https://nccs.res.in/research-highlights/62May 01, 2022 12:00:00 AM GMT+5:30 Oral dysbiosis and its linkage with SARS-CoV-2 infection. Gupta A, Bhanushali S, Sanap A, Shekatkar M, Kharat A, Raut C, Bhonde R, Shouche Y, Kheur S, Sharma A. Microbiological Research Available online 4 May 2022, 127055.https://nccs.res.in/research-highlights/63https://nccs.res.in/research-highlights/63Jun 04, 2022 12:00:00 AM GMT+5:30 Temporal variation in bacterial community profile on patients’ bedsheets in a primary healthcare unit. Varshney S, Kajale S, Khatri S, Gupta D, Sharma A, Sharma S. Archives of Microbiology. 2022 May; 204 (308). https://nccs.res.in/research-highlights/64https://nccs.res.in/research-highlights/64May 01, 2022 12:00:00 AM GMT+5:30Artificial intelligence channelizing protein-peptide interactions  pipeline for host-parasite paradigm in IL-10 and IL-12 reciprocity by SHP-1 Shweta Khandibharad,  Shailza Singh.   Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2022 ; 1868 (10) : 166466.    https://nccs.res.in/research-highlights/65https://nccs.res.in/research-highlights/65Jun 24, 2022 12:00:00 AM GMT+5:30Chavan S, Khuperkar D,  Lonare A,  Panigrahi S,  Bellare J,  Rapole S, Seshadri V.  Joseph J. Ran GTPase links nucleo-cytoplasmic transport to the recruitment of cargoes into small extracellular vesicles. Cellular and Molecular Life Sciences. 2022 July. 79 : 392. https://nccs.res.in/research-highlights/66https://nccs.res.in/research-highlights/66Jul 06, 2022 12:00:00 AM GMT+5:30Barika GK, Sahay O,  Paul D,  Santra MK,  Ezrin gone rogue in cancer progression and metastasis: An enticing therapeutic target. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.  2022 June, 188753 https://nccs.res.in/research-highlights/67https://nccs.res.in/research-highlights/67Jul 06, 2022 12:00:00 AM GMT+5:30Agrawal Y,  Sharma T, Sehbanul Slam , Nadkarni  KS,  Santra MK. F-box protein FBXO41 suppresses breast cancer growth by inducing autophagic cell death through facilitating proteasomal degradation of oncogene SKP2. The International Journal of Biochemistry & Cell Biology.  June 2022,  147 : 106228 https://nccs.res.in/research-highlights/68https://nccs.res.in/research-highlights/68Jul 06, 2022 12:00:00 AM GMT+5:30Zumla A, Traore T, Amao L, Ntoumi F, Sharma A,  Azhar EI,  Abbara A. Reducing the threat of epidemic-prone infections at mass gathering religious events. Lancet. 2022 Jun 27;S0140-6736(22)01194-1.   https://nccs.res.in/research-highlights/69https://nccs.res.in/research-highlights/69Jul 06, 2022 12:00:00 AM GMT+5:30Ghosalkar J,  Sonawane V, Pisal T, Achrekar S, Pujari R, Chugh A, Shastry P,  Joshi K. Prostate Apoptosis Response-4 (Par-4): A Novel Target in Pyronaridine-Induced Apoptosis in Glioblastoma (GBM) Cells.  Cancers.  2022 June ; 14(13), 3198; https://doi.org/10.3390/cancers14133198 https://nccs.res.in/research-highlights/70https://nccs.res.in/research-highlights/70Jul 22, 2022 12:00:00 AM GMT+5:30Varankar SS,  Hari K,  Kartika S, Bapat SA, Jolly MK. Cell geometry distinguishes migration-associated heterogeneity in two-dimensional systems. Computational and System Oncology. 2022 Aug : 2(3) :  e1041 https://nccs.res.in/research-highlights/71https://nccs.res.in/research-highlights/71Aug 10, 2022 12:00:00 AM GMT+5:30Sharma V, Nehra S , Singhal N. Generation of AAVS1-EGFP reporter cell lines from an isogenic pair of trisomy 21 and euploid human iPSCs. Stem Cell Research.2022 Oct; 64: 102890 https://nccs.res.in/research-highlights/72https://nccs.res.in/research-highlights/72Aug 11, 2022 12:00:00 AM GMT+5:30Barman MK, Kailash Chand , Mitra D. Zipper interacting protein kinase (ZIPK) is a negative regulator of HIV-1 replication that is restricted by viral Nef protein through proteasomal degradation. Biochemical and Biophysical Research Communications. 2022 Oct : 625 : 122-127 https://nccs.res.in/research-highlights/73https://nccs.res.in/research-highlights/73Aug 11, 2022 12:00:00 AM GMT+5:30Chauhan NS, Joseph N, Shaligram S,  Chavan N,  Joshi A, Dhotre D, Lodha T .Shouche YS.  Paenibacillus oleatilyticus sp. nov., isolated from soil. Archives of Microbiology. 2022 July : 204:516 https://nccs.res.in/research-highlights/74https://nccs.res.in/research-highlights/74Aug 11, 2022 12:00:00 AM GMT+5:30Gulhane P, Singh S. MicroRNA‐520c‐3p impacts sphingolipid metabolism mediating PI3K/AKT signaling in NSCLC: Systems perspective. Journal of Cellular Biochemistry. 2022 Aug 17;1–14. https://nccs.res.in/research-highlights/75https://nccs.res.in/research-highlights/75Aug 22, 2022 12:00:00 AM GMT+5:30Khandibharad S, Nimsarkar P, Singh S. Mechanobiology of immune cells: Messengers, receivers and followers in leishmaniasis aiding synthetic devices. Current Research in Immunology 2022 Aug ; (3) : 186–198. https://nccs.res.in/research-highlights/76https://nccs.res.in/research-highlights/76Aug 24, 2022 12:00:00 AM GMT+5:30Giri S, Meitei HT, Sonar AS, Shaligram S, Lal G. In vitro-induced Foxp3+ CD8+ regulatory T cells suppress allergic IgE response in the gut. Journal of Leukocyte Biology. PMID: 36000308. Online on 24th August 2022. doi: 10.1002/JLB.5A0122-027R https://nccs.res.in/research-highlights/77https://nccs.res.in/research-highlights/77Aug 25, 2022 12:00:00 AM GMT+5:30Meitei HT, Lal G. T cell receptor signaling in the differentiation and plasticity of CD4+ T cells. Cytokine & Growth Factor Reviews. Available online 20 August 2022. https://doi.org/10.1016/j.cytogfr.2022.08.001. https://nccs.res.in/research-highlights/78https://nccs.res.in/research-highlights/78Aug 25, 2022 12:00:00 AM GMT+5:30Kumar A,  Nimsarkar P,  Singh S.  Systems pharmacology aiding benzimidazole scaffold as potential lead compounds against leishmaniasis for functional therapeutics. Life Sciences . Available online 15 September 2022, 120960 https://nccs.res.in/research-highlights/79https://nccs.res.in/research-highlights/79Sep 19, 2022 12:00:00 AM GMT+5:30Shafi S, Azhar E,  Al-Abri S,  Sharma A, Merali  N,  Al-Tawfiq JA, El-Kafrawy SA,  Zumla  A ,  Shan Lee S. Infectious diseases threats at the Arba'een - a neglected but one of the largest annually recurring mass gathering religious events .  International Journal of Infectious Diseases. 2022 Sep 12;S1201-9712(22)00509-4. https://nccs.res.in/research-highlights/80https://nccs.res.in/research-highlights/80Oct 03, 2022 12:00:00 AM GMT+5:30Tuikhar  N, Kirdat K,  Nair G, Padma S,  Thorat V,  Swetha P,  Sathe S,  Sundararaj R,  Yadav A. Rothia santali sp. nov., endophytic bacteria isolated from sandalwood (Santalum album L.) seedling . Archieve of Microbiology. 2022 Sep 9;204(10):609. https://nccs.res.in/research-highlights/81https://nccs.res.in/research-highlights/81Oct 03, 2022 12:00:00 AM GMT+5:30Mazirea PH, Saha B,  Roya A. Immunotherapy for visceral leishmaniasis: A trapeze of balancing counteractive forces. International Immunopharmacology. 2022 Sept ; 110: 108969 https://nccs.res.in/research-highlights/82https://nccs.res.in/research-highlights/82Oct 03, 2022 12:00:00 AM GMT+5:30Shivalingappa PKM, Singh DK, Sharma V, Arora V, Shiras A, Bapat SA. RBM47 is a Critical Regulator of Mouse Embryonic Stem Cell Differentiation. Stem Cell Reviews and Reports . 2022 Aug 20;1-16.   https://nccs.res.in/research-highlights/84https://nccs.res.in/research-highlights/84Oct 03, 2022 12:00:00 AM GMT+5:30More MH, Varankar SS,  Naik RR,  Dhake RD, Ray P,  Bankar RM, Mali AM,  Subbalakshmi AR, Chakraborty P, Jolly MK, Bapat SA .Multistep Tumor Growth Model of High Grade Serous Ovarian Carcinoma Identifies Hypoxia Associated Signatures. Cells Tissues Organs. 2022 Aug 15 ; doi: 10.1159/000526432. https://nccs.res.in/research-highlights/85https://nccs.res.in/research-highlights/85Oct 03, 2022 12:00:00 AM GMT+5:30Misra, P, Jadhav, AR, Bapat, SA. Single-cell sequencing: A cutting edge tool in molecular medical research. Medical Journal Armed Forces Journal India. 2022 Sep ; 78 :  S7-S13. https://nccs.res.in/research-highlights/86https://nccs.res.in/research-highlights/86Oct 03, 2022 12:00:00 AM GMT+5:30Agarwal D,  Paul S,  Lele P,  Piprode V,  Kawade A,  Hajela N,  Bavdekar A, Parulekar V,  Ginde M,  Paranjape G,   Matsuda K, Hori T, Juvekar S, Lal G*. Changes in immunological parameters by ageing in rural healthy Indian adults and their associations with sex and lifestyle. Scientific Reports. 2022 Sept;  12 : 15012. https://nccs.res.in/research-highlights/87https://nccs.res.in/research-highlights/87Oct 03, 2022 12:00:00 AM GMT+5:30Rani L, Kumar A,  Karhade J, Pandey G, Guha A, Mishra GC,  Wani MR. IL-3 regulates the differentiation of pathogenic Th17 cells. European Journal of Immunololgy. 2022 Sep 8.doi: 10.1002/eji.202149674 https://nccs.res.in/research-highlights/88https://nccs.res.in/research-highlights/88Oct 07, 2022 12:00:00 AM GMT+5:30Challagundla N, Saha B, Agrawal RR. 2022. Insights into inflammasome regulation: cellular, molecular, and pathogenic control of inflammasome activation. Immunologic Research. 2022 Oct;70(5):578-606. https://nccs.res.in/research-highlights/89https://nccs.res.in/research-highlights/89Oct 07, 2022 12:00:00 AM GMT+5:30Gurjar D, Kumar Patra S, Bodhale N, Lenka N, Saha B. . Leishmania intercepts IFN-γR signaling at multiple levels in macrophages. Cytokine. 2022 Sep;157:155956. https://nccs.res.in/research-highlights/90https://nccs.res.in/research-highlights/90Oct 07, 2022 12:00:00 AM GMT+5:30Kapoor-Narula U, Lenka N.* Elucidating the Anti-Tumorigenic Efficacy of Oltipraz, a Dithiolethione, in Glioblastoma.  Cells 2022 Sept 29; 11(19), 3057; https://doi.org/10.3390/cells11193057 https://nccs.res.in/research-highlights/91https://nccs.res.in/research-highlights/91Oct 07, 2022 12:00:00 AM GMT+5:30Palazzo AF,  Joseph  J,  Ming Lim , Thakur KT. Workshop on RanBP2/Nup358 and acute necrotizing encephalopathy. Nucleus. 2022 Dec;13(1):154-169. doi: 10.1080/19491034.2022.2069071. https://nccs.res.in/research-highlights/92https://nccs.res.in/research-highlights/92Oct 07, 2022 12:00:00 AM GMT+5:30Sharma V, Nehra S, Ghosh A, Deshpande JA, Singhal N*. Biphasic cell cycle defect causes impaired neurogenesis in down syndrome. Frontiers in Genetics. 2022 October 12. https://doi.org/10.3389/fgene.2022.1007519 https://nccs.res.in/research-highlights/93https://nccs.res.in/research-highlights/93Oct 17, 2022 12:00:00 AM GMT+5:30Madheshiya PK, Shukla E, Singh J, Bawaria S,  Ansari MY, Chauhan R. Insights into the role of Nup62 and Nup93 in assembling cytoplasmic ring and central transport channel of the nuclear pore complex. Molecular Biology of the Cell. 12 Oct 2022. https://doi.org/10.1091/mbc.E22-01-0027 https://nccs.res.in/research-highlights/94https://nccs.res.in/research-highlights/94Oct 17, 2022 12:00:00 AM GMT+5:30Gupta A , Bhanushali S, Karyakarte R, Joshi S,  Das R,  Shouche Y,  Sharma A. Mycobiome profiling of nasopharyngeal region of SARS-CoV-2 infected individuals. Microbes and Infection. 2022 Oct 11;105059.   https://nccs.res.in/research-highlights/95https://nccs.res.in/research-highlights/95Oct 26, 2022 12:00:00 AM GMT+5:30Saha B, Vannucci L, Saha B, Tenti P, Baral R. Evolvability and emergence of tumor heterogeneity as a space-time function. Cytokine. 2022 Oct 15;161:156061. doi: 10.1016/j.cyto.2022.156061. Online ahead of print. PMID: 36252436 https://nccs.res.in/research-highlights/96https://nccs.res.in/research-highlights/96Nov 04, 2022 12:00:00 AM GMT+5:30Kirdat K, Tiwarekar B, Swetha P, Padma S, Thorat V,  Manjula KN, Kavya N, Sundararaj R,  Yadav A.  Nested Real-Time PCR Assessment of Vertical Transmission of Sandalwood Spike Phytoplasma (' Ca. Phytoplasma asteris') . Biology (Basel). 2022 Oct 12;11(10):1494.doi: 10.3390/biology11101494. https://nccs.res.in/research-highlights/97https://nccs.res.in/research-highlights/97Nov 15, 2022 12:00:00 AM GMT+5:30Sharma A, Rodriguez-Morales AJ, Traore T, Shafi S, El-Kafrawi AS, Esam I Azhar IE, Zumla A. Globalisation of antibiotic-resistant bacteria at recurring mass gathering events. Lancet. November 15, 2022DOI:https://doi.org/10.1016/S0140-6736(22)01995-X. https://nccs.res.in/research-highlights/98https://nccs.res.in/research-highlights/98Nov 16, 2022 12:00:00 AM GMT+5:30Hussain A, Patwekar U,  Mongad DS, Shouche YS.Strategizing the human microbiome for small molecules: approaches and perspectives.  Drug Discovery Today. 2022 Nov 23;103459.   https://nccs.res.in/research-highlights/99https://nccs.res.in/research-highlights/99Nov 30, 2022 12:00:00 AM GMT+5:30Kumkar SN,  Kamble EE,  Chavan NS, Dhotre DP, Pardesi KR*. Diversity of resistant determinants, virulence factors, and mobile genetic elements in Acinetobacter baumannii from India: A comprehensive in silico genome analysis. Frontiers in Cellular and Infection Microbiology. 28 November 2022 https://nccs.res.in/research-highlights/100https://nccs.res.in/research-highlights/100Nov 30, 2022 12:00:00 AM GMT+5:30Mohandasan  R, Thakare  M,  Sunke S,  Iqbal  FM,  Sridharan M, Das  G.Enhanced olfactory memory detection in trap-design Y-mazes allows the study of imperceptible memory traces in Drosophila. Learning Memory.2022;  29(10):355-366. https://nccs.res.in/research-highlights/101https://nccs.res.in/research-highlights/101Nov 30, 2022 12:00:00 AM GMT+5:30Singh A, Mayengbam SS, Yaduvanshi H, Wani MR, Bhat MK. Obesity Programs Macrophages to Support Cancer Progression. Cancer Research. 2022 Dec. https://nccs.res.in/research-highlights/102https://nccs.res.in/research-highlights/102Dec 05, 2022 12:00:00 AM GMT+5:30Singh S*, Samarth N,  Gulhane P. Immunoregulatory framework and the role of miRNA in the pathogenesis of NSCLC -A systematic review. Frontiers in Oncology : Cancer Immunity and Immunotherapy. doi: 10.3389/fonc.2022.1089320   https://nccs.res.in/research-highlights/103https://nccs.res.in/research-highlights/103Dec 05, 2022 12:00:00 AM GMT+5:30Jawale D, Khandibharad S, Singh S. Decoding systems immunological model of sphingolipids with IL-6/IL-17/IL-23 axes in L. major infection. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. Available online 7 December 2022, 159261 https://nccs.res.in/research-highlights/104https://nccs.res.in/research-highlights/104Dec 07, 2022 12:00:00 AM GMT+5:30Sharma A, McCloskey B, David S. Hui, Rambia A,  Zumla A, Traore T, Shafi S, Sherif A. El-Kafrawy,  Azhar EI,  Zumla A, Alfonso J. Rodrigues-Morales. Global mass gathering events and deaths due to crowd surge, stampedes, crush and physical injuries – Lessons from the Seoul Halloween and other disasters. Travel Medicine and Infectious Disease. Available online 11 December 2022, 102524 https://nccs.res.in/research-highlights/105https://nccs.res.in/research-highlights/105Dec 13, 2022 12:00:00 AM GMT+5:30Azhar EI, Hui DS, McCloskey B, El-Kafrawy SA, Sharma A, Maeurer M, Shui-Shan Lee, Zumla A. The Qatar FIFA World Cup 2022 and camel pageant championships increase risk of MERS-CoV transmission and global spread. Lancet. 2022 Dec. DOI:https://doi.org/10.1016/S2214-109X(22)00543-5. https://nccs.res.in/research-highlights/106https://nccs.res.in/research-highlights/106Dec 16, 2022 12:00:00 AM GMT+5:30Chaudhry R,  Antony  B,  Batra P, Om Prakash. Editorial on the first webinar of the Anaerobic Forum of India. Anaerobe. 2022 Dec.; 78: 102650. https://nccs.res.in/research-highlights/107https://nccs.res.in/research-highlights/107Jan 03, 2023 12:00:00 AM GMT+5:30Mahor H,  Mukherjee  A, Sarkar  A, Saha  B. Anti-leishmanial therapy: Caught between drugs and immune targets. Experimental Parasitology. 2022 Dec;  108441. https://nccs.res.in/research-highlights/108https://nccs.res.in/research-highlights/108Jan 03, 2023 12:00:00 AM GMT+5:30Mondal A, Barik GK, Sarkar S, Mondal D, Ahmad M, Vijayakanth T, Mondal J, Santra MK, Talukdar P. Nontoxic Artificial Chloride Channel Formation in Epithelial Cells by Isophthalic Acid-Based Small Molecules. Chemistry : A European Journal. 2022 Nov 18. doi: 10.1002/chem.202202887. Epub ahead of print. PMID: 36399427. https://nccs.res.in/research-highlights/109https://nccs.res.in/research-highlights/109Jan 11, 2023 12:00:00 AM GMT+5:30Rayrikar AY, Wagh GA, Santra MK, Patra C. Ccn2a-FGFR1-SHH signaling is necessary for intervertebral disc homeostasis and regeneration in adult zebrafish. Development. 2023 Jan 1;150(1):dev201036. doi: 10.1242/dev.201036. Epub 2023 Jan 6. PMID: 36458546. https://nccs.res.in/research-highlights/110https://nccs.res.in/research-highlights/110Jan 11, 2023 12:00:00 AM GMT+5:30Iyer K, Mitra A, Mitra D. Identification of 5' upstream sequence involved in HSPBP1 gene transcription and its downregulation during HIV-1 infection. Virus Research. 2023 Jan 15;324:199034.  https://nccs.res.in/research-highlights/111https://nccs.res.in/research-highlights/111Feb 01, 2023 12:00:00 AM GMT+5:30Pandey N, Jain R,  Dhakar K, Sharma A,  Pandey A. A reduction in temperature induces bioactive red pigment production in a psychrotolerant Penicillium sp. GEU_37 isolated from Himalayan soil. Fungal Biology. Available online 25 January 2023. https://nccs.res.in/research-highlights/112https://nccs.res.in/research-highlights/112Feb 01, 2023 12:00:00 AM GMT+5:30Chand K, Barman MK, Ghosh P,  Mitra D. DNAJB8 facilitates autophagic-lysosomal degradation of viral Vif protein and restricts HIV-1 virion infectivity by rescuing APOBEC3G expression in host cells.  FESEB Journal. 2023 Feb.; 37(3) : e22793. https://nccs.res.in/research-highlights/113https://nccs.res.in/research-highlights/113Feb 08, 2023 12:00:00 AM GMT+5:30Nehra S, Sharma V, Umrani M, Singhal N. Generation of integration-free Down syndrome and isogenic euploid human induced pluripotent stem cells. Stem Cell Research.  2023 Feb ; 67: 103041.   https://nccs.res.in/research-highlights/114https://nccs.res.in/research-highlights/114Feb 09, 2023 12:00:00 AM GMT+5:30Ghare U, Narvekar S, Lodha T, Mallebhari R, Dastager S, Barvkar VT, Dhotre D,Karmalkar NR, Pable AA. Bacterial Communities and Diversity of Western GhatsSoil: A Study of a Biodiversity Hotspot. Current Microbiology. 2023 Feb 17;80(4):108. https://nccs.res.in/research-highlights/116https://nccs.res.in/research-highlights/116Mar 06, 2023 12:00:00 AM GMT+5:30Josi A, Thite S, Lodha T, Joseph  N.  Mengade P.  Genomic insights of an alkaliphilic bacterium Halalkalibacter alkaliphilus sp. nov. isolated from an Indian Soda Lake.    Antonie van Leeuwenhoek . February 2023 https://nccs.res.in/research-highlights/117https://nccs.res.in/research-highlights/117Mar 06, 2023 12:00:00 AM GMT+5:30Kirdat K,  Tiwarekar B,  Sathe S, Yadav A.*  From sequences to species: Charting the phytoplasma classification and taxonomy in the era of taxogenomics. Frontiers in  Microbiology : Evolutionary and Genomic Microbiology.  2023 Mar : 14 https://nccs.res.in/research-highlights/118https://nccs.res.in/research-highlights/118Mar 13, 2023 12:00:00 AM GMT+5:30Betallu MA,  Bhalara SR,  Sapnar BK,  Tadke VB,  Meena K,  Srivastava A, Kundu GC, Gorain M. Hybrid Inorganic Complexes as Cancer Therapeutic Agents: In-vitro Validation. Nanotheranostics . 2023 Mar; 7(3): 270-280. https://nccs.res.in/research-highlights/119https://nccs.res.in/research-highlights/119Mar 21, 2023 12:00:00 AM GMT+5:30Arkat S, Poovitha S, Vijayakumar A, Dhat R, Sitasawad SL, Mahapatra NR.Regulation of peroxiredoxin-3 gene expression under basal and hyperglycemic conditions: Key roles for transcription factors Sp1, CREB and NF-κB. Biochimica et Biophysica Acta - Molecular Basis of Disease . 2023 Mar 16:166691. https://nccs.res.in/research-highlights/120https://nccs.res.in/research-highlights/120Mar 25, 2023 12:00:00 AM GMT+5:30Puri D, Kelkar A, Gaurishankar B, Subramanyam D. Balance between autophagy and cell death is maintained by Polycomb-mediated regulation during stem cell differentiation. FEBS Journal. 2023 Mar;290(6):1625-1644. https://nccs.res.in/research-highlights/121https://nccs.res.in/research-highlights/121Mar 25, 2023 12:00:00 AM GMT+5:30Chand K, Barman MK, Ghosh P, Mitra D. DNAJB8 facilitates autophagic-lysosomal degradation of viral Vif protein and restricts HIV-1 virion infectivity by rescuing APOBEC3G expression in host cells.  FASEB Journal. 2023 Mar;37(3):e22793. https://nccs.res.in/research-highlights/122https://nccs.res.in/research-highlights/122Mar 25, 2023 12:00:00 AM GMT+5:30Apte S, Bhutda S, Ghosh S, Sharma K, Barton TE, Dibyachintan S, Sahay O, Roy S, Sinha AR, Adicherla H, Rakshit J, Tang S, Datey A, Santra S, Joseph J, Sasidharan S, Hammerschmidt S, Chakravortty D, Oggioni MR, Santra MK, Neill DR, Banerjee A. An innate pathogen sensing strategy involving ubiquitination of bacterial surface proteins. Science Advances. 2023 Mar 22;9(12):eade1851. https://nccs.res.in/research-highlights/123https://nccs.res.in/research-highlights/123Mar 25, 2023 12:00:00 AM GMT+5:30Guhe V,  Ingale P, Tambekar A.  Singh S.*. Systems biology of Autophagy in Leishmanial Infection and Its Diverse Role in Precision Medicine . Frontiers in Molecular Biosciences . Sec. Molecular Diagnostics and Therapeutics. 2023 April ; 10. | doi: 10.3389/fmolb.2023.1113249. https://nccs.res.in/research-highlights/124https://nccs.res.in/research-highlights/124Apr 06, 2023 12:00:00 AM GMT+5:30Petersen  E, Hui  DS,  Nachega JB, Ntoumi  F, Goletti  D , Aklillu  E , Sharma A, Nyirenda T, Yeboah-Manu  D , Satta G , Da Costa  C, Azhar EI , Bockarie M ,  Al-Abri  S,  McHugh  TD ,  Rodriguez-Morales AJ , Varghese  GM,  Zumla A.  End of the Bedaquiline patent – a crucial development for moving forward affordable drugs, diagnostics, and vaccines for infectious diseases in low- and middle-income countries. International Journal of Infectious Diseases. 2023 Apr 6;S1201-9712(23)00517-9. https://nccs.res.in/research-highlights/125https://nccs.res.in/research-highlights/125Apr 10, 2023 12:00:00 AM GMT+5:30Gulhane P, Singh S, Unraveling the Post-Translational Modifications and therapeutical approach in NSCLC pathogenesis. Translational Oncology.  33 (2023) 101673. https://nccs.res.in/research-highlights/126https://nccs.res.in/research-highlights/126Apr 18, 2023 12:00:00 AM GMT+5:30Dhat R, Mongad D, Raji S,  Arkat S, Mahapatra NR,  Singhal N,  Sitasawad SL*. Epigenetic modifier alpha‑ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart. Epigenetics & Chromatin. 2023 May 27 ;  16 (12). https://nccs.res.in/research-highlights/127https://nccs.res.in/research-highlights/127May 01, 2023 12:00:00 AM GMT+5:30Sahabram Dewala S , Rahul Bodkhe, Yogesh Nimonkar, O M Prakash, Vineet Ahuja, Govind K Makharia, Yogesh S Shouche *. Human small-intestinal gluten-degrading bacteria and its potential implication in celiac disease. Journal of Bioscience. 2023 July ;48:18. https://nccs.res.in/research-highlights/128https://nccs.res.in/research-highlights/128Jul 17, 2023 12:00:00 AM GMT+5:30Gupta A, Dutt V,  Sharma N,  Kajale S, Bhatt A, Shafi S,  Azhar E, Zumla A, Sharma A* . Examining the microbial composition of natural springs in Bhaderwah, Jammu and Kashmir, India. Environmental Monitoring and Assessment. 2023 July; 195 ( 949 ). https://nccs.res.in/research-highlights/129https://nccs.res.in/research-highlights/129Jul 17, 2023 12:00:00 AM GMT+5:30Sharma A*, Karande M,  Zumla A. Advancing sewage surveillance at mass gathering events for reducing transmission of antimicrobial resistant bacterial pathogens. Travel Medicine and Infectious Disease. 13 July 2023, 102619 https://nccs.res.in/research-highlights/130https://nccs.res.in/research-highlights/130Jul 17, 2023 12:00:00 AM GMT+5:30Chauhan M, Kimothi A, Sharma A,  Pandey A*. Cold adapted Pseudomonas: ecology to biotechnology. Frontiers in Microbiology :  Sec. Extreme Microbiology. 2023 July ;  14 ; 1218708 https://nccs.res.in/research-highlights/131https://nccs.res.in/research-highlights/131Jul 19, 2023 12:00:00 AM GMT+5:30Shrivas VL, Choudhary AK, Shidture S,  Rambia A, P. Hariprasad, Sharma A,  Sharma S. Organic amendments modulate the crop yield and rhizospheric bacterial community diversity: a 3-year field study with Cajanus cajan . International Microbiology. 2023 July. https://nccs.res.in/research-highlights/132https://nccs.res.in/research-highlights/132Jul 28, 2023 12:00:00 AM GMT+5:30Jiya N, Shede P,  Sharma A*. Diversity and composition of fungal communities across diverse environmental niches in Antarctica Author links open overlay panel. Polar Science.  Available online 5 August 2023, 100973 https://nccs.res.in/research-highlights/133https://nccs.res.in/research-highlights/133Aug 09, 2023 12:00:00 AM GMT+5:30Aadil KR, Nathani A, Rajendran R,  Sharma CS. Lenka N*, Gupta P.  Investigation of human hair keratin-based nanofibrous scaffold for skin tissue engineering application. Drug Delivery and Translational Research. 2023 Aug. https://nccs.res.in/research-highlights/134https://nccs.res.in/research-highlights/134Aug 21, 2023 12:00:00 AM GMT+5:30Singh K, Keer A, Aakib Zed, Jasmeen R, Mishra K,  Mourya N,  Paul D, Dhotre D,  Shouche Y*. High Antibiotic Resistance in Indian Sewage Shows Distinct Trends and might be Disjoint from in-situ Antibiotic Levels. Water, Air, and Soil Pollution. 2023 Aug.; 234 : 467. https://nccs.res.in/research-highlights/135https://nccs.res.in/research-highlights/135Aug 25, 2023 12:00:00 AM GMT+5:30Rambia A, Veluchamy C, Rawat JM, Jamdhade MD, Purohit S, Pawar KD, Rajasekaran C, Rawat B. Sharma A.  Revealing bacterial and fungal communities of the untapped forest and alpine grassland zones of the Western-Himalayan region.  International Microbiology.  14 September 2023.   https://nccs.res.in/research-highlights/136https://nccs.res.in/research-highlights/136Sep 18, 2023 12:00:00 AM GMT+5:30Khandibharad S, Singh S. Immuno-metabolic signaling in Leishmaniasis: Insights Gained from Mathematical Modeling .  Bioinformatics Advances,  14 September 2023   https://nccs.res.in/research-highlights/137https://nccs.res.in/research-highlights/137Sep 18, 2023 12:00:00 AM GMT+5:30Mayengbam SS,  Singh A, Yaduvanshi H,  Bhati FK,  Deshmukh B, Athavale D,  Ramteke PL, Bhat MK. Cholesterol reprograms glucose and lipid metabolism to promote proliferation in colon cancer cells. Cancer & Metabolism. 2023 Sept; 11 https://nccs.res.in/research-highlights/138https://nccs.res.in/research-highlights/138Sep 18, 2023 12:00:00 AM GMT+5:30Bahir MM, Rajendran A, Pattanayak D, Lenka N*. Fabrication and characterization of ceramic-polymer composite 3D scaffolds and demonstration of osteoinductive propensity with gingival mesenchymal stem cells. RSC Advances. 2023 Sep 8;13(38):26967-26982. https://nccs.res.in/research-highlights/139https://nccs.res.in/research-highlights/139Sep 27, 2023 12:00:00 AM GMT+5:30Barik GK, Sahay O, Mukhopadhyay A, Manne RK, Islam S, Roy A, Nath S, Santra MK*. FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis. Cell Death and Diseases. 2023 Sep 22;14(9):623. https://nccs.res.in/research-highlights/140https://nccs.res.in/research-highlights/140Sep 27, 2023 12:00:00 AM GMT+5:30Khilwani R. Singh S*. Systems Biology and Cytokines Potential Role in Lung Cancer Immunotherapy Targeting Autophagic Axis.  Biomedicines 2023, 11(10), 2706; https://doi.org/10.3390/biomedicines11102706 https://nccs.res.in/research-highlights/141https://nccs.res.in/research-highlights/141Oct 09, 2023 12:00:00 AM GMT+5:30Sahay O*, Barik  GK, Islam  S*. FBXW10: a male-biased E3 ligase in liver cancer.  Trends in Cancer. 2023 Sep 27:S2405-8033(23)00188-7. doi: 10.1016/j.trecan.2023.09.004. https://nccs.res.in/research-highlights/142https://nccs.res.in/research-highlights/142Oct 09, 2023 12:00:00 AM GMT+5:30Karmakar S,  Mishra A,  Pal P,  Lal G. Effector and cytolytic function of natural killer cells in anti-cancer immunity.  Journal of Leukocyte Biology.  11 October 2023https://doi.org/10.1093/jleuko/qiad126. https://nccs.res.in/research-highlights/143https://nccs.res.in/research-highlights/143Oct 17, 2023 12:00:00 AM GMT+5:30Sharma A, Gupta B, Petersen E, Lee SS,  Zumla A. Enhancing preparedness for reducing transmission and globalisation of Antimicrobial Resistance at the Ardh Kumbh Mela 2025, the world's largest recurring religious mass gathering. International Journal of Infectious Diseases. October 16, 2023. https://doi.org/10.1016/j.ijid.2023.10.014 https://nccs.res.in/research-highlights/144https://nccs.res.in/research-highlights/144Oct 17, 2023 12:00:00 AM GMT+5:30Chauhan M, Kimothi A,  Sharma A, Adhikari BS, Pandey A. Diploknema butyracea (Roxb.) H. J. Lam: a mid-Himalayan treasure trove. Biodiversity. 17 Oct 2023. https://nccs.res.in/research-highlights/145https://nccs.res.in/research-highlights/145Oct 18, 2023 12:00:00 AM GMT+5:30Taunk  K , Paul D, Dabhi  R, Venkatesh  C, Jajula  S,  Naik  V,  Tamhankar  A, Naiya T,  Santra  MK*, Rapole S*. A single step and rapid protein extraction protocol developed for cell lines and tissues: Compatible for gel based and gel free proteomic approaches. Methods. 2023 Oct 31:S1046-2023(23)00181-0. https://nccs.res.in/research-highlights/146https://nccs.res.in/research-highlights/146Nov 08, 2023 12:00:00 AM GMT+5:30Sridhar A, More AS, Jadhav AR,  Patil  K,  Mavlankar A, Dixit VM, Bapat SA*, Pattern recognition in the landscape of seemingly random chimeric transcripts. Computational and Structural Biotechnology Journal. 2023 Nov ; 21: 5153–5164. doi: 10.1016/j.csbj.2023.10.028 https://nccs.res.in/research-highlights/147https://nccs.res.in/research-highlights/147Nov 14, 2023 12:00:00 AM GMT+5:30Utage B,* Patole  M, Nagvenkar P, Gacche R.* Prosopis juliflora (Sw.) DC.induces apoptotic-like programmed cell death in Leishmania donovani via over production of oxidative stress,mitochondrial dysfunction and ATP depletion. Journal of Traditional and Complementary Medicine.  2023 Nov; 13 (6) : 611-622 https://nccs.res.in/research-highlights/148https://nccs.res.in/research-highlights/148Nov 20, 2023 12:00:00 AM GMT+5:30Kadam P, Khisti M, Ravishankar V, Barvkar V, Dhotre D, Sharma A, Shouche Y, Zinjarde S* .Recent advances in production and applications of ectoine, a compatible solute of industrial relevance. Bioresource Technology. 2023 Nov;  130016. https://nccs.res.in/research-highlights/149https://nccs.res.in/research-highlights/149Nov 20, 2023 12:00:00 AM GMT+5:30Tripathi A, Iyer K, Mitra D*. HIV-1 replication requires optimal activation of the unfolded protein response. FEBS Letters. 2023 Nov.; DOI: 10.1002/1873-3468.14772 https://nccs.res.in/research-highlights/150https://nccs.res.in/research-highlights/150Nov 30, 2023 12:00:00 AM GMT+5:30Jiya N, Kajale S,  Kaldate A,  Khudai W,  Gupta B, Oza Y,  Sharma A*. Lipingzhangella rawalii sp. nov., a novel halophile isolated from Sambhar Salt Lake, Rajasthan, India.  Archives of  Microbiology.  December 2023 Dec. 15 ; 206 : 22.  https://nccs.res.in/research-highlights/151https://nccs.res.in/research-highlights/151Dec 19, 2023 12:00:00 AM GMT+5:30Yadav KK,  Nimonkar Y,  Green SJ,  Dewala  S,  Dhanorkar MN,  Sharma R,  Rale VR,   Om Prakash.  Anaerobic growth and drug susceptibility of versatile fungal pathogen Scedosporium apiospermum. iScience. 2023 Nov 17; 26(11): 108304. https://nccs.res.in/research-highlights/152https://nccs.res.in/research-highlights/152Dec 26, 2023 12:00:00 AM GMT+5:30Jafarzadeh A, Gurjar D, Bodhale N, Jafarzadeh S, Nemati M, Sharifi I, Saha B. Aberrant expression of SOCS impairs the anti-leishmanial immune response. Cytokine. 2023 Dec 7;174:156461. https://nccs.res.in/research-highlights/153https://nccs.res.in/research-highlights/153Dec 26, 2023 12:00:00 AM GMT+5:30Bhadane D, Kamble D, Deval M, Das S, Sitasawad S*. NOX4 alleviates breast cancer cell aggressiveness by co-ordinating mitochondrial turnover through PGC1α/Drp1 axis.  Cellular Signalling. 2023 Dec 11:111008. doi: 10.1016/j.cellsig.2023.111008. Epub ahead of print. PMID: 38092301. https://nccs.res.in/research-highlights/154https://nccs.res.in/research-highlights/154Dec 26, 2023 12:00:00 AM GMT+5:30Sharma A*, Gupta B,  Ghosh A, Sharma S, Rodriguez-Morales AJ, Zumla A, Memish ZA. Raising awareness and mitigating risk of transmission of antimicrobial resistance during the upcoming 2024 Gangasagar religious mass gathering. New Microbes and New Infections. 2023 Dec;  101213 https://nccs.res.in/research-highlights/155https://nccs.res.in/research-highlights/155Dec 19, 2023 12:00:00 AM GMT+5:30 Sonar SA, Meitei HT, Karmakar, S  Mishra A, Inamdar S, Lenka N, Lal G*. Th17 cell promotes apoptosis of IL-23R+ neurons in experimental autoimmune encephalomyelitis. Clinical Immunology  5th January 2024.  DOI: 10.1016/j.clim.2024.109898 . PMID: 38185267 https://nccs.res.in/research-highlights/156https://nccs.res.in/research-highlights/156Jan 11, 2024 12:00:00 AM GMT+5:30Khandibharad S, Singh S*.  Synthetic Biology for Combating Leishmaniasis. Frontiers in Microbiology Sec. Infectious Agents and Disease Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1338749 https://nccs.res.in/research-highlights/157https://nccs.res.in/research-highlights/157Jan 11, 2024 12:00:00 AM GMT+5:30Khilwani R, Singh S*. Traversing through the mechanistic event analysis in IL6 and IL7 signaling for a new therapeutic paradigm in NSCLC. International Journal of Molecualr Science. 2024 Jan :  25(2), 1216; https://doi.org/10.3390/ijms25021216 https://nccs.res.in/research-highlights/158https://nccs.res.in/research-highlights/158Jan 19, 2024 12:00:00 AM GMT+5:30Karmakar S,  Mishra A, Pal  P, Lal G*. Effector and cytolytic function of natural killer cells in anticancer immunity. Journal of Leukocyte Biology. 2024 Jan 19;115(2):235-252. https://nccs.res.in/research-highlights/159https://nccs.res.in/research-highlights/159Jan 24, 2024 12:00:00 AM GMT+5:30Dasila K, Pandey A, Sharma A, Samant SS,  Singh M. Endophytic fungi from Himalayan silver birch as potential source of plant growth enhancement and secondary metabolite production.  Brazilian Journal of Microbiology. 2024 Jan.                                                              https://doi.org/10.1007/s42770-024-01259-4 https://nccs.res.in/research-highlights/160https://nccs.res.in/research-highlights/160Feb 01, 2024 12:00:00 AM GMT+5:30Yadav A*,  Maurya A,  Bhavsar Y,  Teware R,  Bhatt A,   Elaine DaCosta, Thorat V, Kirdat K, Dastager SG. Fictibacillus fluitans sp. nov., isolated from freshwater pond.  Archives of Microbiology. 2024 Jan; 206, 70. https://doi.org/10.1007/s00203-023-03794-4 https://nccs.res.in/research-highlights/161https://nccs.res.in/research-highlights/161Feb 01, 2024 12:00:00 AM GMT+5:30Khandibharad S, Singh S*. Single cell ATAC sequencing identifies sleepy macrophages during reciprocity of cytokines in L.major infection. Microbiolgy Specturm.  2024 Jan ;  https://doi.org/10.1128/spectrum.03478-23   https://nccs.res.in/research-highlights/162https://nccs.res.in/research-highlights/162Feb 02, 2024 12:00:00 AM GMT+5:30Guhe V, Singh S*. Targeting peptide based therapeutics: Integrated computational and experimental studies of autophagic regulation in host-parasite interaction. ChemMedChem. 2024 Feb; https://doi.org/10.1002/cmdc.202300679 https://nccs.res.in/research-highlights/163https://nccs.res.in/research-highlights/163Feb 06, 2024 12:00:00 AM GMT+5:30Vijayakumar MV. The Code of Contract: A Primer for Academia. Journal of Scientific & Industrial Research.  2024 March :  . 83 ( 3) : 292-299. https://nccs.res.in/research-highlights/164https://nccs.res.in/research-highlights/164Mar 15, 2024 12:00:00 AM GMT+5:30Jiya1 N, Kajale S, Jani K,  Keer A, Markan C, Chavan M,  Khandare AV,  Jamdhade MD,   Zumla A,  Sharma A*. Insights into bacterial communities: multidrug-resistant and biofilm-forming bacteria in poultry droppings. Current Science.  2024 March; 562 ; 126 (6) : 552-568. https://nccs.res.in/research-highlights/165https://nccs.res.in/research-highlights/165Mar 15, 2024 12:00:00 AM GMT+5:30Prajakta Ingale, Shailza Singh https://nccs.res.in/research-highlights/166https://nccs.res.in/research-highlights/166Mar 27, 2024 12:00:00 AM GMT+5:30Desai M , Hemant , Deo A, Naik J, Dhamale P, Kshirsagar A,  Bose  T,  Majumdar A. Mrj is a chaperone of the Hsp40 family that regulates Orb2 oligomerization and long-term memory in Drosophila. PLOS Biology. April 22, 2024. https://doi.org/10.1371/journal.pbio.3002585 Dr. Amitabha Majumdar & team's research published in PLoS Biology reveal the crucial role played by the Mrj protein (a chaperone involved in protein folding) in maintaining long-term memory in fruit flies. These are valuable insights that could help understand memory-related disorders in humans https://nccs.res.in/research-highlights/167https://nccs.res.in/research-highlights/167May 01, 2024 12:00:00 AM GMT+5:30Thakare MR, Choudhary P,  Pydah B, Suhas Sunke S,  Yadav RSP,  Agrawal P, Das G. DIETS: a simple and sensitive assay to measure and control the intake of complex solid foods, like high-fat diets, in Drosophila. eLife.  https://doi.org/10.7554/eLife.97706.1 https://nccs.res.in/research-highlights/168https://nccs.res.in/research-highlights/168May 09, 2024 12:00:00 AM GMT+5:30Memish ZA,*  Kattan RF, Ebrahim SH, Sharma A, Azhar EI, Zumla A.Proactive surveillance for avian influenza H5N1 and other priority pathogens at mass gathering events. Lancet. May 15, 2024. DOI:https://doi.org/10.1016/S2468-2667(24)00103-8 https://nccs.res.in/research-highlights/169https://nccs.res.in/research-highlights/169May 16, 2024 12:00:00 AM GMT+5:30Jiya N, Ghosh R, Shede  P, Sharma A. Comparative analysis of bacterial diversity in accumulated snow and exposed sediments across Antarctic Islands. Brazilian Journal of Microbiology .  15 May 2024 May :   https://nccs.res.in/research-highlights/170https://nccs.res.in/research-highlights/170May 16, 2024 12:00:00 AM GMT+5:30Avchar R, Giri G​, Thakkar L,  Sharma A,  José Paulo Sampaio.​ Wickerhamiella lachancei f.a. sp. nov., a novel ascomycetous yeast species isolated from flowers of Lantana camara in India.  International Journal of Systematic and Evolutionary Microbiology, j74 (5) ; 2024 May: https://doi.org/10.1099/ijsem.0.006365 https://nccs.res.in/research-highlights/171https://nccs.res.in/research-highlights/171May 16, 2024 12:00:00 AM GMT+5:30Yadav A, Teware R, Bhatt A, Bhavsar Y, Maurya A, Thorat V, Vemuluri VR, Kirdat K. Ureibacillus aquaedulcis sp. nov., isolated from freshwater well and reclassification of Lysinibacillus yapensis and Lysinibacillus antri as Ureibacillus yapensis comb. nov. and Ureibacillus antri comb. Nov. Archives of  Microbiology. 2024 May 2;206(5):242. https://nccs.res.in/research-highlights/172https://nccs.res.in/research-highlights/172May 24, 2024 12:00:00 AM GMT+5:30Verma S, Dalabehera S, Maurya R, Singh D, Prasher B, Pandey R, Bapat S, Ramalingam S, Sachidanandan C.  Generation of an induced pluripotent stem cell line IGIBi18-A from an Indian patient with Rubinstein Taybi Syndrome . Stem Cell Research 2024 :  78 : 103456. https://nccs.res.in/research-highlights/173https://nccs.res.in/research-highlights/173May 31, 2024 12:00:00 AM GMT+5:30Taunk  K, Jajula S, Bhavsar PP ,  Choudhari M, Bhanuse  S, Tamhankar  A , Naiya T, Kalita B,  Rapole S *.The prowess of metabolomics in cancer research: current trends, challenges and future perspectives. Molecular and  Cellular Biochemistry. 2024 May 30. doi: 10.1007/s11010-024-05041-w. https://nccs.res.in/research-highlights/174https://nccs.res.in/research-highlights/174Jun 04, 2024 12:00:00 AM GMT+5:30Mote RD,  Tiwari M,  Yadavalli N,  Rajan R, Subramanyam D*.  A high-throughput screen in mESCs to identify the cross-talk between signaling, endocytosis, and pluripotency. Cell Biology International.  2024 June ; 48 (6).  https://doi.org/10.1002/cbin.12168. https://nccs.res.in/research-highlights/175https://nccs.res.in/research-highlights/175Jun 07, 2024 12:00:00 AM GMT+5:30Thite S, Godbole D, Debnath M, Bhatt A, Yadav A, Lodha T, Joseph N, Kirdat K, Boruah D, Sharma R.  Joshi A*. Alkalimonas mucilaginosa sp. nov. and Alkalimonas cellulosilytica sp. nov. isolated from alkaline Lonar lake, India. Antonie van Leeuwenhoek. 2024 June ; 117 (88) https://nccs.res.in/research-highlights/176https://nccs.res.in/research-highlights/176Jun 12, 2024 12:00:00 AM GMT+5:30Jajula S, Naik V, Kalita B, Yanamandra U, Sharma S,  Chatterjee T,  Bhanuse S, Bhavsar PP,  Taunk K, Rapole S*. Integrative proteome analysis of bone marrow interstitial fluid and serum reveals candidate signature for acute myeloid leukemia. Journal of Proteomics. 2024 July ; 303 : 105224 https://nccs.res.in/research-highlights/177https://nccs.res.in/research-highlights/177Jun 20, 2024 12:00:00 AM GMT+5:30Yadav M, Roy N, Mandal K, Nagpure M,  Santra MK, Guchhait SK. Rutaecarpine-inspired scaffold-hopping strategy and Ullmann cross-coupling based synthetic approach: Identification of pyridopyrimidinone-indole based novel anticancer chemotypes. Bioorganic & Medicinal Chemistry. 2024 July: 109 ;  117799. https://nccs.res.in/research-highlights/178https://nccs.res.in/research-highlights/178Jul 02, 2024 12:00:00 AM GMT+5:30Ghate  NB, Nadkarni KS,  Barik GK,  Tat  SS,  Sahay O,  Santra MK*.  Histone ubiquitination: Role in genome integrity and chromatin organization.  Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2024 Sept; 1867 (3) :  195044. https://nccs.res.in/research-highlights/179https://nccs.res.in/research-highlights/179Jul 02, 2024 12:00:00 AM GMT+5:30Tripathi A, Dasgupta A, Mitra D*. Measuring Endoplasmic Reticulum Stress and Unfolded Protein Response in HIV-1 Infected T-Cells and Analyzing its Role in HIV-1 Replication. JOVE Journal.  Published: June 14th, 2024. 10.3791/66522 https://nccs.res.in/research-highlights/180https://nccs.res.in/research-highlights/180Jul 09, 2024 12:00:00 AM GMT+5:30Guhe V,  Tambekar A, Singh S*. Computational and Experimental Approaches Towards Understanding the Role of ATG8 in Autophagy: A Therapeutic Paradigm in Leishmaniasis. The Protein Journal. 2024 July; https://nccs.res.in/research-highlights/181https://nccs.res.in/research-highlights/181Jul 10, 2024 12:00:00 AM GMT+5:30Khandibharad S,  Singh S*. Mechanistic study of inhibitory peptides with SHP-1 in hypertonic environment for infection model. Biochimica et Biophysica Acta (BBA) - General Subjects. 2024 July:  130670. https://nccs.res.in/research-highlights/182https://nccs.res.in/research-highlights/182Jul 11, 2024 12:00:00 AM GMT+5:30McCloskey B, Memish ZA, Sharma A, Traore T, Parker S, Zumla A.  Confronting heat-related illnesses and deaths at mass gathering religious and sporting events. Lancet : Planetary Health . 2024 July:  DOI:https://doi.org/10.1016/S2542-5196(24)00161-X.   https://nccs.res.in/research-highlights/183https://nccs.res.in/research-highlights/183Jul 18, 2024 12:00:00 AM GMT+5:30Kalarikkal M, Saikia R,  Oliveira L,  Bhorkar Y,  Lonare A,  Varshney P,  Dhamale P,   Majumdar A,  Joseph J*. Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling.  EMBO Reports . 2024 July. https://www.embopress.org/doi/full/10.1038/s44319-024-00204-8   DETAILS   Video Synopsis https://nccs.res.in/research-highlights/184https://nccs.res.in/research-highlights/184Jul 18, 2024 12:00:00 AM GMT+5:30Kanti Kar M, Mahata R, Srimayee S, Haloi N,  Kumar R, Lindahl E,  Santra MK,  Manna D*.    β-Carboline-based light and pH dual stimuli-responsive ion transporters induce cancer cell death.  Chemical Communication . 2024 July; https://doi.org/10.1039/D4CC02232G https://nccs.res.in/research-highlights/185https://nccs.res.in/research-highlights/185Jul 22, 2024 12:00:00 AM GMT+5:30Veluchamy C, Sharma A*, Thiagarajan K.  Assessing the impact of heavy metals on bacterial diversity in coastal regions of Southeastern India. Environmental Monitoring and Assessment.  August 2024 Aug; 196 (828) .   https://nccs.res.in/research-highlights/186https://nccs.res.in/research-highlights/186Aug 22, 2024 12:00:00 AM GMT+5:30Petersen E,  Elton  L,  Haider N,  McHugh TD, Osman Dar,  Sharma A,  Pam Luka , Tieble Traore , Edgar Simulundu,  Azhar  EI,  Ntoumi  F,  Bockarie  MJ,   Memish ZA,  Zumla A. The role of new dengue vaccines in curtailing the emerging global threat of dengue outbreaks arising from mass gathering sporting and religious events. International Journal of Infectious Diseases.  2024 Aug; 107216. https://nccs.res.in/research-highlights/187https://nccs.res.in/research-highlights/187Aug 22, 2024 12:00:00 AM GMT+5:30Nadodkar SD,  Karande M, Pawar MG,  Dhume AV,  Sharma A, Salgaonkar BB. Deciphering the salt induced morphogenesis and functional potentials of Hortaea werneckii; a black pigmented halotolerant yeast isolated from solar saltern. Fungal Biology.  2024 Nov ; 128 (7) : 2113-2126. https://nccs.res.in/research-highlights/188https://nccs.res.in/research-highlights/188Aug 28, 2024 12:00:00 AM GMT+5:30Sharma A*, McCloskey B, Parker S. Shafi S, Azhar EI, Memish ZA, Zumla A. The Kumbh Mela religious mass gathering in India: reducing risks for crowd-surge associated deaths and crush injuries.  Journal of Travel Medicine, 2024 Aug ; taae116, https://nccs.res.in/research-highlights/189https://nccs.res.in/research-highlights/189Aug 28, 2024 12:00:00 AM GMT+5:30Roy  PK , Paul A, Khandibharad  S, Kolhe  SD, Farooque  QSS,  Singh  S, Singh S. Mechanistic and structural insights into vitamin B2 metabolizing enzyme riboflavin kinase from Leishmania donovani. International Journal of Biological Macromolecules 2024 Aug 7;278(Pt 1):134392.doi: 10.1016/j.ijbiomac.2024.134392.   https://nccs.res.in/research-highlights/190https://nccs.res.in/research-highlights/190Aug 28, 2024 12:00:00 AM GMT+5:30Srinivasan  K , Nampoothiri M,  Khandibharad  S,   Singh S,   Nayak AG,  Hariharapura RC.  Proteomic diversity of Russell's viper venom: exploring PLA2 isoforms, pharmacological effects, and inhibitory approaches. Archives of Toxicology . 2024 Aug 24.doi: 10.1007/s00204-024-03849-5.   https://nccs.res.in/research-highlights/191https://nccs.res.in/research-highlights/191Aug 28, 2024 12:00:00 AM GMT+5:30Jawale D, Khandibharad S, Singh S. Innate Immune Response and Epigenetic Regulation: A Closely Intertwined Tale in Inflammation. Advanced Biology.12 September 2024 https://doi.org/10.1002/adbi.202400278 https://nccs.res.in/research-highlights/192https://nccs.res.in/research-highlights/192Sep 13, 2024 12:00:00 AM GMT+5:30Khandibharad S, Singh S*. Immunometabolic Circuits in Infection for Advancing Host Directed Therapies. JOVE - Journal of Visualized Experiments. September 13th, 2024. DOI:10.3791/66980 https://nccs.res.in/research-highlights/193https://nccs.res.in/research-highlights/193Sep 18, 2024 12:00:00 AM GMT+5:30Samarth N, Gulhane P, Singh S*. Investigation through naphtho[2,3-a]pyrene on mutated EGFR mediated autophagy in NSCLC: Cellular model system unleashing therapeutic potential. IUBMB Life. 14 September 2024 https://doi.org/10.1002/iub.2914 https://nccs.res.in/research-highlights/194https://nccs.res.in/research-highlights/194Sep 18, 2024 12:00:00 AM GMT+5:30Bhati FK, Bhat MK*. An anti-neoplastic tale of metformin through its transport. Life Science.  November 2024, 357 (15). 123060. https://doi.org/10.1016/j.lfs.2024.123060. https://nccs.res.in/research-highlights/195https://nccs.res.in/research-highlights/195Oct 15, 2024 12:00:00 AM GMT+5:30Singh SB, Rajput SS, Sharma A, Kataria S, Dutta P,  Ananthanarayanan V, Nandi A, Patil S, Majumdar A, Subramanyam D*.Pathogenic Huntingtin aggregates alter actin organization and cellular stiffness resulting in stalled clathrin mediated endocytosis. eLife.  October 2024.  e 98363. https://doi.org/10.7554/eLife.98363 https://nccs.res.in/research-highlights/196https://nccs.res.in/research-highlights/196Oct 15, 2024 12:00:00 AM GMT+5:30Sharma A, Rodriguez-Morales  AJ, Srivastava S, Memish ZA, Zumla A. Public Health Challenges at the Upcoming Kumbh Mela 2025: Addressing the Mpox global public health emergency of international concern. Travel Medicine and Infectious Disease. October 2024, 102771. https://nccs.res.in/research-highlights/197https://nccs.res.in/research-highlights/197Oct 15, 2024 12:00:00 AM GMT+5:30Tambekar A, Guhe V, Singh S*. The cGAS-STING Mediated Crosstalk between Innate Immunity and Autophagy in Leishmaniasis using Mathematical Modeling: Uncovering New Therapeutic Avenues. Archives of Biochemistry and Biophysics. 31 October 2024, 110201. https://doi.org/10.1016/j.abb.2024.110201. https://nccs.res.in/research-highlights/198https://nccs.res.in/research-highlights/198Nov 01, 2024 12:00:00 AM GMT+5:30Halder N, Yadav S, Lal G *.  Neuroimmune communication of the cholinergic system in gut inflammation and autoimmunity.  Autoimmunity Reviews.  December 2024 : 23 (12) : 103678. https://nccs.res.in/research-highlights/199https://nccs.res.in/research-highlights/199Nov 08, 2024 12:00:00 AM GMT+5:30Bano S, More S, Mongad DS,  Khalique A, Dhotre DP, Bhat MK,  Seshadri V*. Prolonged exposure to insulin might cause epigenetic alteration leading to insulin resistance. FEBS OpenBio. 29 October 2024 : 13891. https://nccs.res.in/research-highlights/200https://nccs.res.in/research-highlights/200Nov 08, 2024 12:00:00 AM GMT+5:30Yu-Yang J,   Kumar S,  Turkewitz AP.   The secretory pathway in Tetrahymena is organized for efficient constitutive secretion at ciliary pockets. iScience.  November 15, 2024.  27 : 11111123. https://nccs.res.in/research-highlights/201https://nccs.res.in/research-highlights/201Nov 08, 2024 12:00:00 AM GMT+5:30Kumar S, Das S,  Jiya N, Sharma A, Saha  C, Sharma P, Tamang S,   Thakur N. Bacterial Diversity Along the Geothermal Gradients: Insights from the High-altitude Himalayan Hot Spring Habitats of Sikkim.  Current Research in Microbial Sciences.  November 2024, 100310. https://nccs.res.in/research-highlights/202https://nccs.res.in/research-highlights/202Nov 12, 2024 12:00:00 AM GMT+5:30Khilwani R, Singh S.*  Leveraging Evolutionary Immunology in Interleukin-6 and Interleukin-17 Signaling for Lung Cancer Therapeutics. ACS Pharmacology & Translational Science. November 22. 2024.  https://doi.org/10.1021/acsptsci.4c00412. https://nccs.res.in/research-highlights/203https://nccs.res.in/research-highlights/203Nov 25, 2024 12:00:00 AM GMT+5:30Narayanan A, More AS,  Talreja  M,  Mali AM ,  Boya Vinay  S,  Bapat SA.*  A novel ITGB8 transcript variant sustains ovarian cancer cell survival through genomic instability and altered ploidy on a mutant p53 background . Journal of Ovarian Research.. 2024 Nov 6;17(1):218. doi: 10.1186/s13048-024-01538-6. https://nccs.res.in/research-highlights/204https://nccs.res.in/research-highlights/204Nov 26, 2024 12:00:00 AM GMT+5:30Pampana SVL,  Biswas B, Jajula S,  Rapole S, Ummanni R*.  Proteomic Analysis of Microsomal Proteins Reveals That MVP Is Crucial for the Secretion of GDF-15, Which in Turn Promotes the Neuroendocrine Differentiation of PCa Cells. Journal of Proteome Research. October 29, 2024. https://doi.org/10.1021/acs.jproteome.4c00694. https://nccs.res.in/research-highlights/205https://nccs.res.in/research-highlights/205Dec 04, 2024 12:00:00 AM GMT+5:30Guhe V, Singh S*. Uncovering the Significance of JNK/AKT Axis in the Autophagic Regulation of Leishmania major Infection. Molecular Microbiology. 03 December 2024. https://doi.org/10.1111/mmi.15333 https://nccs.res.in/research-highlights/206https://nccs.res.in/research-highlights/206Dec 04, 2024 12:00:00 AM GMT+5:30Gaikwad N, Sarwade R, Halder S, Agarwal G, Seshadri V*. HuD regulates apoptosis in N2a cells by regulating Msi2 expression. PLoS One. 2024 December 16 : https://doi.org/10.1371/journal.pone.0315535. https://nccs.res.in/research-highlights/207https://nccs.res.in/research-highlights/207Dec 27, 2024 12:00:00 AM GMT+5:30Rahman M, Uddin M, Ashrafi SAA, Rahman KM, Paul KK, Ferdous M, Sarker R, Haque F,  Sharma A,  Papakonstantinou  D. The 2023 fatal dengue outbreak in Bangladesh highlights a paradigm shift of geographical distribution of cases. Epidemiology & Infection . 07 January 2025. DOI: https://doi.org/10.1017/S0950268824001791 https://nccs.res.in/research-highlights/208https://nccs.res.in/research-highlights/208Jan 08, 2025 12:00:00 AM GMT+5:30Mondal S, Karande M, Srivastava S, Sharma A, Sharma S, Ghosh A. Unravelling the microbiome perspective to variations in tea metabolome. Industrial Crops and Products. January 2025, 223 : 120129. https://doi.org/10.1016/j.indcrop.2024.120129. https://nccs.res.in/research-highlights/209https://nccs.res.in/research-highlights/209Jan 14, 2025 12:00:00 AM GMT+5:30Negi S, Singh P, Rawat B, Sharma A, Rawat JM, Semwal P. Unearthing the landscape: a bibliometric exploration of hairy root culture research over the past 41 years.  In Vitro Cellular & Developmental Biology - Plant . 13 January 2025. https://doi.org/10.1007/s11627-024-10488-z. https://nccs.res.in/research-highlights/210https://nccs.res.in/research-highlights/210Jan 14, 2025 12:00:00 AM GMT+5:30Dasgupta A,  Tripathi A,  Mitra A,  Ghosh P,  Santra MK,  Mitra D*. Human microRNA miR-197-3p positively regulates HIV-1 virion infectivity through its target DDX52 by stabilizing Vif protein expression. Journal of Biological Chemistry . January 2025, 108198. https://nccs.res.in/research-highlights/211https://nccs.res.in/research-highlights/211Jan 21, 2025 12:00:00 AM GMT+5:30Joshi A, Thite S, Godbole D, Boruah D,  Sindhu DK,  Prabhu A, Joseph N,  Yadav A,  Sharma A,  Lodha T. Genomic insights into Marinospirillum alkalitolerans sp. nov., a novel PHB producing bacterium from an Indian impact crater, and an emended description of family Oceanospirillaceae.  Antonie van Leeuwenhoek.               10 February 2025. https://doi.org/10.1007/s10482-024-02059-4. https://nccs.res.in/research-highlights/213https://nccs.res.in/research-highlights/213Feb 21, 2025 12:00:00 AM GMT+5:30Tyagi R,  Oza Y,  Sarkar A, Shivay YS, Sharma A*, Sharma S. Mapping the pathobiome and rhizosphere microbiome in Cajanus cajan-Fusarium interaction across agroclimatic zones and crop varieties.  Plant and Soil. 20 February 2025,  https://doi.org/10.1007/s11104-025-07208-w. https://nccs.res.in/research-highlights/214https://nccs.res.in/research-highlights/214Feb 21, 2025 12:00:00 AM GMT+5:30Verma N, Chavan N, Aulakh KS,  Sharma A, Shouche Y,  Ramana VV. Temporal Dynamics of Microbial Community Composition and Antimicrobial Resistance in a Mass Gathering Setting Using Culturomics and Metagenomic Approaches.  Journal of Epidemiology and Global Health .  March 2025. 15 ( 41 )  https://nccs.res.in/research-highlights/215https://nccs.res.in/research-highlights/215Mar 26, 2025 12:00:00 AM GMT+5:30Jiya N, Sanap A, Srivastava S, Kheur S,, Sharma A*. Microbial Signatures in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma: Implications of Tobacco and Betel Quid Consumption. Journal of Oral Biosciences Available online 22 March 2025, 100656. https://nccs.res.in/research-highlights/216https://nccs.res.in/research-highlights/216Mar 26, 2025 12:00:00 AM GMT+5:30More N, Joseph J*. Disruption of ER–mitochondria contact sites induces autophagy-dependent loss of P-bodies through the Ca2+-CaMKK2-AMPK pathway Icon for The Forest of Biologists. Journal of  Cell Science. March 2025. 138 (5): . JCS263652. https://nccs.res.in/research-highlights/217https://nccs.res.in/research-highlights/217Mar 26, 2025 12:00:00 AM GMT+5:30Pawar GM, Naik SV, Naik TJ, Karande M,  Sharma A*, Salgaonkar BB. Biodegradation of crustacean shell waste by Halococcus salsus GUAg20; a chitinolytic and proteolytic halophilic archaeon. International Biodeterioration & Biodegradation. April 2025,  202 : 106102. https://nccs.res.in/research-highlights/218https://nccs.res.in/research-highlights/218Apr 28, 2025 12:00:00 AM GMT+5:30Abhishek Keer, Oza Y, Mongad D,  Ramakrishnan D,  Dhotre D,  Ahmed A,  Zumla A, Shouche Y, Sharma A*, Assessment of seasonal variations in antibiotic resistance genes and microbial communities in sewage treatment plants for public health monitoring.  Environmental Pollution.  2025 May, 375 :126367. https://doi.org/10.1016/j.envpol.2025.126367. https://nccs.res.in/research-highlights/219https://nccs.res.in/research-highlights/219May 07, 2025 12:00:00 AM GMT+5:30Khandibharad S,  Gulhane P, Singh S*.  Computational Cellular Mathematical Model Aids Understanding the cGAS-STING in NSCLC Pathogenicity. Bio-protocol. Vol 15, Iss 5, Mar 5, 2025 DOI: 10.21769/BioProtoc.5223. https://nccs.res.in/research-highlights/220https://nccs.res.in/research-highlights/220May 19, 2025 12:00:00 AM GMT+5:30Kirdat K, Patwekar U, Jain K, Mubarak M, Choudhary P, Thakkar L, Thorat V, Madamwar D, Lodha T, Yadav A*. Genomic insights into Neopusillimonas aestuarii sp. nov., a novel estuarine bacterium with adaptations for ectoine biosynthesis and stress tolerance. Antonie van Leeuwenhoek. May 2025, 118:82. https://link.springer.com/article/10.1007/s10482-025-02093-w                   https://nccs.res.in/research-highlights/221https://nccs.res.in/research-highlights/221Jun 05, 2025 12:00:00 AM GMT+5:30Sharma S,  Das J, Subramanyam D*.  Traffic flow and signals: Regulating the movement within cells. Current Opinion in Cell Biology. June 2025, 94 : 102518. https://doi.org/10.1016/j.ceb.2025.102518. https://nccs.res.in/research-highlights/222https://nccs.res.in/research-highlights/222Jun 05, 2025 12:00:00 AM GMT+5:30Pal P, Wahi P, Sahu A, Lal G. Pro- and Anti-Inflammatory Role of Complement in Cancer. European Journal of Immunology.  June 2026, 55 (6). E51767. https://doi.org/10.1002/eji.202451767   https://nccs.res.in/research-highlights/223https://nccs.res.in/research-highlights/223Jun 13, 2025 12:00:00 AM GMT+5:30Tiwari M, Dingankar M, Das J, Sreelekshmi S R,  Solanki A, Subramanyam D*.  CLCa mediates a novel cross-talk between Wnt secretion and actin organization.  Life Science Alliance.  2025 May 2;8(7):e202402962. doi: 10.26508/lsa.202402962. https://nccs.res.in/research-highlights/224https://nccs.res.in/research-highlights/224Jun 19, 2025 12:00:00 AM GMT+5:30Avchar R*,  Pontes A​,  Lachance MA, Sharma A,  Sampaio JP. Metschnikowia ratanii f.a. sp. nov., an ascomycetous yeast species isolated from flowers of Lantana camara in India. International Journal of Systematic and Evolutionary Microbiology.  July 2025 ; 75( 7). . https://doi.org/10.1099/ijsem.0.006851. https://nccs.res.in/research-highlights/225https://nccs.res.in/research-highlights/225Jul 22, 2025 12:00:00 AM GMT+5:30Bertagna MA,  Bright LJ ,  Fei Ye ,  Jiang  YY,  Sarkar D,  Pradhan A,  Kumar S,  Gao S,  Turkewitz AP,   Tsypin LMZ.  Inferring gene-pathway associations from consolidated transcriptome datasets: an interactive gene network explorer for Tetrahymena thermophila. NAR Genomics and Bioinformatics. June  2025,  7(2) lqaf067. https://doi.org/10.1093/nargab/lqaf067 https://nccs.res.in/research-highlights/226https://nccs.res.in/research-highlights/226Jul 25, 2025 12:00:00 AM GMT+5:30Dubey S, Bhattacharjee A, Oza Y, Saxena SS, Pradhan S,  Sharma A, Sharma S*. Harnessing SynComs for rhizosphere engineering to alleviate salt stress in Vigna radiata: From lab experiments to the field.  Plant Physiology and Biochemistry.  July 2025, 110304 https://nccs.res.in/research-highlights/227https://nccs.res.in/research-highlights/227Aug 01, 2025 12:00:00 AM GMT+5:30Kavungal D, Morro E, Senthil TK, Dagli B,  Lashuel HA,  Altug H. Nanoplasmonic Infrared Microarray Sensor Enabling Structural Protein Biomarker-Based Drug Screening for Neurodegenerative Diseases. Advanced Science  July 2025. https://doi.org/10.1002/advs.202500320 https://nccs.res.in/research-highlights/228https://nccs.res.in/research-highlights/228Aug 06, 2025 12:00:00 AM GMT+5:30Bhavsar PP, Kalita B, Taunk K,  Rapole S*. Decoding the key hallmarks of chemoresistance: A proteomic tale from breast cancer research. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. October 2025,  1880 (5) : 189404 https://nccs.res.in/research-highlights/229https://nccs.res.in/research-highlights/229Aug 07, 2025 12:00:00 AM GMT+5:30Bhanuse SG, Kalita B, Taunk K,  Rapole S*. Unveiling the multifaceted role of MZB1 in health and disease toward potential therapeutics. A comprehensive review. International Journal of Biological Macromolecules. September 2025 321 (4) : 146399. https://nccs.res.in/research-highlights/230https://nccs.res.in/research-highlights/230Aug 07, 2025 12:00:00 AM GMT+5:30Veluchamy C,  Sharma A, Thiagarajan K.  Assessment of heavy metal pollution and human health risk along the Southeast coast of India: A comprehensive ecotoxicological study. Marine Pollution Bulletin.  December 2025, 221 : 118512.  https://nccs.res.in/research-highlights/231https://nccs.res.in/research-highlights/231Aug 07, 2025 12:00:00 AM GMT+5:30Yadav S, Veliventi SS, Bhandari S, Gangurde S, Naik S, Bhagwat SN.  Kumar S.* Decoding GNAO1 mutations using Caenorhabditis elegans model system: past approaches and future prospectives. Frontiers in Cellular Neuroscience July 2025,  19 : 1633744. https://doi.org/10.3389/fncel.2025.1633744 https://nccs.res.in/research-highlights/232https://nccs.res.in/research-highlights/232Sep 01, 2025 12:00:00 AM GMT+5:30Bhattacharya D, Jiya N, Mondal S, Acharya A, Chatterjee A, Bakshi U, Sharma A*.Bacterial diversity in the freshwater sponges of Sundarban and their potential role in biomonitoring toxic element pollution. Microbiology Spectrum. August 2025, 02149-25.  https://nccs.res.in/research-highlights/233https://nccs.res.in/research-highlights/233Sep 01, 2025 12:00:00 AM GMT+5:30Guha A, Prasad A, Ashokkumar K, Pal P, Sahu P, Wani MR, Lal G* (2025) Complement C3 deficiency inhibits osteoclast differentiation and prevents ovariectomy-induced osteoporosis. Journal of  Immunolgy. Aug. 2025. vkaf180. https://doi.org/10.1093/jimmun/vkaf180 https://nccs.res.in/research-highlights/234https://nccs.res.in/research-highlights/234Sep 01, 2025 12:00:00 AM GMT+5:30Oza Y, Sharma SS, Karande M, Khanal M, Pradhan A,  Rawat S. Sharma A*. Symbiotic association of rhizobiome with newly discovered Gastrodia indica, a holomycotrophic orchid species from eastern Himalayas. Biologia.         30 August 2025. https://doi.org/10.1007/s11756-025-02019-x https://nccs.res.in/research-highlights/235https://nccs.res.in/research-highlights/235Sep 04, 2025 12:00:00 AM GMT+5:30Kumar G, Khandibharad S, Singh S*. Targeting IL-6/STAT3 signaling to mitigate sarcopenia: Insights from immuno-metabolic crosstalk in NSCLC. Biochemical and Biophysical Research Communications. 30 October 2025, 786 : 152727 https://nccs.res.in/research-highlights/236https://nccs.res.in/research-highlights/236Oct 01, 2025 12:00:00 AM GMT+5:30Mandal K, Barik GK, Santra MK*. Overcoming resistance to anti-PD-L1 immunotherapy: mechanisms, combination strategies, and future directions. Molecular Cancer.  Oct. 2025 ;24(1):246. doi: 10.1186/s12943-025-02400-z.  https://nccs.res.in/research-highlights/237https://nccs.res.in/research-highlights/237Oct 08, 2025 12:00:00 AM GMT+5:30Gupta R, Shravan S, Agwane SB, Bankar RM, Bapat SA*. ID8 cells manifest phenotypic plasticity and molecular heterogeneity of high-grade serous ovarian cancer in response to the local tissue niche. Scientific  Report. Oct. 2025;15(1):34626. doi: 10.1038/s41598-025-18264-8.  https://nccs.res.in/research-highlights/238https://nccs.res.in/research-highlights/238Oct 09, 2025 12:00:00 AM GMT+5:30Narayanan A, Guha S, Mali A, Bapat SA*. Targeting mitochondrial translation and OXPHOS in high-grade serous ovarian carcinoma eliminates stem-like cells. Cell Death & Disease. Oct.  2025 ;  16 (676). https://nccs.res.in/research-highlights/239https://nccs.res.in/research-highlights/239Oct 08, 2025 12:00:00 AM GMT+5:30Susmitha A, Reddy GJ*.  3D-hNCAnH for Simultaneous Backbone Resonance Assignment and One and Two Bond N–Cα Coupling Constants for Secondary Structural Prediction of Proteins. Magnetic Resonance in Chemistry. 2025; 0:1-11. https://doi.org/10.1002/mrc.70040 https://nccs.res.in/research-highlights/241https://nccs.res.in/research-highlights/241Oct 17, 2025 12:00:00 AM GMT+5:30Jugran AK, Bisht Y,  Kumar A, Rautela K, Sharma H, Sharma A, Sekar KC,  Bhatt ID, Nautiyal S, Singh AV, Mishra PK. Unlocking the potential of Himalayan common bean for sustainable agriculture through physical, biochemical, and genetic profiling. Biocatalysis and Agricultural Biotechnology. Volume 69, November 2025, 103804.    https://doi.org/10.1016/j.bcab.2025.103804               https://nccs.res.in/research-highlights/242https://nccs.res.in/research-highlights/242Oct 17, 2025 12:00:00 AM GMT+5:30Gone NV, Sharma T, Joshi R, Upreti A, Santra S*, Sanjayan GJ. Repurposed ciprofloxacin derivatives as potent autophagic-type anticancer agents. Bioorganic & Medicinal Chemistry Letters.  January 2026 ; 130 (1) : 130432. https://doi.org/10.1016/j.bmcl.2025.130432. https://nccs.res.in/research-highlights/243https://nccs.res.in/research-highlights/243Oct 17, 2025 12:00:00 AM GMT+5:30Khandibharad S, Singh S*. Epigenetic landscape of Leishmania-host interactions.  Epigenomics . 16 Oct 2025. 17501911.2025.2574836  https://doi.org/10.1080/17501911.2025.2574836 https://nccs.res.in/research-highlights/244https://nccs.res.in/research-highlights/244Oct 17, 2025 12:00:00 AM GMT+5:30Rani D, Khandibharad S,  Singh S*. Integrative Modeling of FOXO-Mediated Autophagy in NSCLC: Linking cGAS-STING Signaling to IL-6 Dynamics. Frontiers in Oncology.  Sec. Molecular and Cellular Oncology. Nov. 2025. https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1689137. https://nccs.res.in/research-highlights/245https://nccs.res.in/research-highlights/245Nov 04, 2025 12:00:00 AM GMT+5:30Khilwani R, Singh S*.  Dual signaling cascade regulating gut-lung axis in Interleukin-6/Interleukin-17 for NSCLC immuno pathogenesis. Frontiers in Immunology .Sec. Immunological Tolerance and Regulation. Nov. 2025. https://nccs.res.in/research-highlights/246https://nccs.res.in/research-highlights/246Nov 12, 2025 12:00:00 AM GMT+5:30Khandibharad S,  Singh S*.  Evaluating LeishPepThera (PepA) as an Immuno-Therapeutic for Leishmania major Infection. iScience. 114064. November 14, 2025. https://nccs.res.in/research-highlights/247https://nccs.res.in/research-highlights/247Nov 17, 2025 12:00:00 AM GMT+5:30Yaduvanshi H, Deshmukh B, Singh A, Mayengbam SS, Bhat MK*.  Anti-tumor response by targeting glucose metabolism and depletion of membrane cholesterol in breast cancer and melanoma cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2026 Jan; 1873 (1) : 120088 https://nccs.res.in/research-highlights/248https://nccs.res.in/research-highlights/248Nov 27, 2025 12:00:00 AM GMT+5:30Dutta P, Maiti I,  Mondal KS,  Ghose A, Chauhan R*.  Maiti S*. Kaptin Functions as a Barbed-End Binding Protein to Control Actin Filament Dynamics. Journal of Molecular Biology . 20 November 2025, 169554. https://nccs.res.in/research-highlights/249https://nccs.res.in/research-highlights/249Nov 27, 2025 12:00:00 AM GMT+5:30Jawale D, Singh S*. A Novel Peptide Antagonist for SATB1 in the Immune Response to Leishmania Infection. Microbial Pathogenesis.  21 November 2025, 108191.  https://nccs.res.in/research-highlights/250https://nccs.res.in/research-highlights/250Nov 28, 2025 12:00:00 AM GMT+5:30Pradhan A, Tadasare N,  Sarkar D,  Maurya V,  Bansal LK,  Turkewitz AP, Kumar S*.  Maturation stage-specific V-ATPase disassembly explains the neutral pH of mature mucocysts, lysosome related organelles in Tetrahymena thermophila. Journal of Cell Science.. 2025 Nov 7 ; 264146.  https://nccs.res.in/research-highlights/251https://nccs.res.in/research-highlights/251Nov 28, 2025 12:00:00 AM GMT+5:30Tat SS,  Mandal K, Sharma T, Ghate NB, Barik GK, Gachhe RN, Santra MK*.  The multifaceted role of PUMA in cell death pathways: its therapeutic potential across cancer types.  Cell Communication and Signaling.                                                                                                       20 November 2025 ; 23 : 499.    https://nccs.res.in/research-highlights/252https://nccs.res.in/research-highlights/252Dec 02, 2025 12:00:00 AM GMT+5:30Yadav S, Veliventi SS, Meena S, Koelle MR, Kumar S*.  Rapid purification of brain protein complexes containing active and inactive forms of the G protein Gαo. PLoS One. 2025 Dec 4;20(12):e0337998. doi: 10.1371/journal.pone.0337998. eCollection 2025. PMID: 41343492 https://nccs.res.in/research-highlights/253https://nccs.res.in/research-highlights/253Dec 15, 2025 12:00:00 AM GMT+5:30Khandibharad S, Singh S*. Synthetic bioengineered macrophages for immune cell functions in infectious disease cellular therapy. FEBS Letters. 20 December 2025. https://doi.org/10.1002/1873-3468.70254. https://nccs.res.in/research-highlights/254https://nccs.res.in/research-highlights/254Dec 22, 2025 12:00:00 AM GMT+5:30Veluchamy C, Nallakaruppan N, Nachiappan K, Sekaran M,  Vartak RB, Zambare RB, Panneerselvam S, Chandrasekaran R, Sharma A, Thiagarajan K*.  Marine microbial bioprospecting and bioactive bioproducts: seven decades of discovery and contemporary perspectives.  Frontiers in Marine Science.  Sec. Marine Biotechnology and Bioproducts. 11 December 2025, Volume 12 - 2025.  https://nccs.res.in/research-highlights/255https://nccs.res.in/research-highlights/255Dec 29, 2025 12:00:00 AM GMT+5:30Choudhari M, Taunk K, Kalita B,  Rapole S*. VDAC1: at the crossroads of cancer signalling and metabolism. Expert Review of  Proteomics. 2025 Dec 26:1-17. doi: 10.1080/14789450.2025.2607512. https://nccs.res.in/research-highlights/256https://nccs.res.in/research-highlights/256Dec 29, 2025 12:00:00 AM GMT+5:30Meitei HT, Kulkarni N, Shirolkar A, Rapole S, Sharma PK, Mujeeb VR, Srivastava S, Lal G*. CCL20-CCR6 signaling alters the metabolic reprogramming to promote the pathogenic Th17 cell differentiation. iScience. Jan 2025; 29 (1) : 114385 https://nccs.res.in/research-highlights/257https://nccs.res.in/research-highlights/257Jan 01, 2026 12:00:00 AM GMT+5:30Naik TJ, Pawar GM,Karande M, Sharma A, Salgaonkar BB. Halophilic archaeon Haloarcula argentinensis GUAg231: A promising strain for co-production of polyhydroxyalkanoates and carotenoids. International Journal of Biological Macromolecules. January 2026; 340 (2) : 150191 https://nccs.res.in/research-highlights/258https://nccs.res.in/research-highlights/258Jan 22, 2026 12:00:00 AM GMT+5:30Sharma A*, Gupta B. Managing scale and complexity in recurring religious mass gatherings: Preparedness for the Nashik Kumbh Mela 2027. Mass Gathering Medicine. September 2026; 5 :100049. https://nccs.res.in/research-highlights/259https://nccs.res.in/research-highlights/259Jan 22, 2026 12:00:00 AM GMT+5:30Deshmukh B, Kumar AA, Bhat MK*. Obesity and cancer: Relevance of DNA damage response. Translational Oncology. March 2026; 65 : 102657.   https://nccs.res.in/research-highlights/260https://nccs.res.in/research-highlights/260Jan 22, 2026 12:00:00 AM GMT+5:30Deshmukh B, Kumar AA, Bhat MK*. Obesity and cancer: Relevance of DNA damage response. Translational Oncology. March 2026; 65 : 102657.   https://nccs.res.in/research-highlights/261https://nccs.res.in/research-highlights/261Jan 22, 2026 12:00:00 AM GMT+5:30Patra SK, Gurjar D, Saha B,  Lenka N* . CD40 Stimulation Improves Osteogenesis from Mesenchymal Stem Cells via the Activation of TGF-β. Stem Cell Reviews and Reports . 20 February 2026. https://doi.org/10.1007/s12015-026-11077-w https://nccs.res.in/research-highlights/262https://nccs.res.in/research-highlights/262Feb 24, 2026 12:00:00 AM GMT+5:30Md Asaduzzaman, Hasan MN,  Nasif MAO, Mataraarachchi D,,Ehsan Larik EA, Onyango J, Billah M, Sharma A, Rahman M, Haque F, Papakonstantinou D, Paudyal P, Haider N. Unravelling the dengue surge in South Asia during 2000–2023: pattern, trend, genomics, and key determinants. Epidemiology & Infection.  06 February 2026. https://nccs.res.in/research-highlights/263https://nccs.res.in/research-highlights/263Feb 24, 2026 12:00:00 AM GMT+5:30Tamang S, Sherpa MT, Kumar S, Najar IN, Sharma P, Das S, Jiya N, Sharma A, Pandey P, Thakur N. Exploring the bacterial diversity and its antibiotic resistance in Kabru Glacier ice cores, Sikkim Himalaya. Frontiers in Microbiology, . Sec. Extreme Microbiology. 28 January 2026. 16.  https://nccs.res.in/research-highlights/264https://nccs.res.in/research-highlights/264Feb 24, 2026 12:00:00 AM GMT+5:30Jiya N​, Khudai W​,  Gupta B​, Sindhu DK​, Shrivastava V​, Thite S​, Karodi P​, Vemuluri VR, ​ Sharma A*. Deinococcus pantiae sp. nov., a UV-resistant bacterium isolated from a lake in Schirmacher Oasis, Antarctica . International Journal of Systematic and Evolutionary Microbiology. 18 February 2026 , 76 (2). https://doi.org/10.1099/ijsem.0.007071. https://nccs.res.in/research-highlights/265https://nccs.res.in/research-highlights/265Feb 24, 2026 12:00:00 AM GMT+5:30Kirdat K, Mubarak M, Choudhary P,  Sathe S, Yadav A*. Genomic landscape reveals the dominance of self-catalytic, high-copy group II introns in PMU-deficient complete genomes of PWB phytoplasmas. Journal of Microbiology.  Published online: March 19, 2026 https://nccs.res.in/research-highlights/266https://nccs.res.in/research-highlights/266Mar 24, 2026 12:00:00 AM GMT+5:30Mahataa R, Santra MK*. Importance of E3 Ligases for Preserving Genome Integrity : Progress and Challenges. Molecular and Cellular Biology . 2026 Mar 17:1-26. doi: 10.1080/10985549.2026.2638203. https://nccs.res.in/research-highlights/267https://nccs.res.in/research-highlights/267Mar 24, 2026 12:00:00 AM GMT+5:30Joseph N*, Madamwar D, Gangtire M,  Jiya N, Patel V, Joshi A, Karodi P, Sharma A . Description and genomic insights of Niallia laureatilytica sp. nov., isolated from coastal ecosystem.  Antonie van Leeuwenhoek. 2026 Mar 20; 119 (73)  https://nccs.res.in/research-highlights/268https://nccs.res.in/research-highlights/268Mar 24, 2026 12:00:00 AM GMT+5:30Dixit K, Busi SB,  Ahmed A,  Kshirsagar A, Jäger C,  Singh A, Shah V,  Saroj SD,  Ahuja V,  Wilmes P, Shouche Y,  Makharia G,  Dhotre D*. Multi-meta-omics reveal distinct microbial genomic profiles and metabolic dysregulation in non-celiac gluten sensitivity.  mSphere 30 March 2026. https://doi.org/10.1128/msphere.00856-25 https://nccs.res.in/research-highlights/269https://nccs.res.in/research-highlights/269Mar 31, 2026 12:00:00 AM GMT+5:30Nampoothiri D, Bhardwaj R, Deshpande  N, Abnave P*. Chromatin-derived histone proteins from Schmidtea mediterranea function as innate antimicrobial effectors. Frontiers in Cellular and Infection Microbiology :  Sec. Adaptive & Innate Immunity in Infection. 20 April 2026, 16 :1816580.  https://doi.org/10.3389/fcimb.2026.1816580. https://nccs.res.in/research-highlights/270https://nccs.res.in/research-highlights/270Apr 21, 2026 12:00:00 AM GMT+5:30Pradhan B, Senthil TK, Wagner J, Gallardo R, Orlando G, Vleeschouwer MD, Zorzini V,  Madine J, Louros N, Neher JJ,  Rousseau F, Schymkowitz J*. Atomic structures of medin and Aβ fibrils reveal polymorphic remodeling in mixed amyloid systems. Nature Communications. April 2026,  2475. https://doi.org/10.1038/s41467-026-72515-4  https://nccs.res.in/research-highlights/271https://nccs.res.in/research-highlights/271May 05, 2026 12:00:00 AM GMT+5:30Jadhav AR, Sahoo S , Kuber YL, Hatwar K, Varanwal A, Tanwar K ,  Palwankar S, Chatrasal G,  Mali AM, Bapat SA*. Emergence and evolution of chimeric pseudogenes (φgenes) contribute to genetic and functional diversity of the human genome. Nucleic Acids Research, May 2026,  54 (8) : gkag375. https://doi.org/10.1093/nar/gkag375 https://nccs.res.in/research-highlights/272https://nccs.res.in/research-highlights/272May 07, 2026 12:00:00 AM GMT+5:30Gupta KK,  Vijayvargiya M, Paul G, Philip NS, Chauhan R*. 3HVIface: Sequence-Based Deep Learning for Decoding Human-Virus Protein-Protein Interfaces. Frontiers in Bioinformatics. Sec. Protein Bioinformatics. 08 May 2026, (7) : 1813796. https://nccs.res.in/research-highlights/273https://nccs.res.in/research-highlights/273May 11, 2026 12:00:00 AM GMT+5:30