National Centre for Cell Science

Debashis Mitra, Ph.D.

Ex-Director, CDFD and Professor of Eminence

Email

dmitra@nccs.res.in

Publications and Patents

List of selected 5 publications

1. Augustine T, Chaudhary P, Gupta K, Islam S, Ghosh P, Santra MK, Mitra D. Cyclin F/FBXO1 Interacts with HIV-1 Viral Infectivity Factor (Vif) and Restricts Progeny Virion Infectivity by Ubiquitination and Proteasomal Degradation of Vif Protein through SCF (cyclin F) E3 Ligase Machinery. J Biol Chem. 292:5349-5363, 2017.
2. Chaudhary P, Khan SZ, Rawat P, Augustine T, Raynes DA, Guerriero V, Mitra, D. HSP70 binding protein 1 (HspBP1) suppresses HIV-1 replication by inhibiting NF-κB mediated activation of viral gene expression. Nucleic Acids Res. 44:1613-1629, 2016.
3. Rawat P, Mitra D. Cellular heat shock factor 1 positively regulates human immunodeficiency virus-1 gene expression and replication by two distinct pathways. Nucleic Acids Res. 39:5879-5892, 2011.
4. Kumar, M. and Mitra D. Heat shock protein 40 is necessary for human immunodeficiency virus-1 Nef mediated enhancement of viral gene expression and replication. J. Biol. Chem. 280: 40041-40050, 2005
5. Ladha, J. S., Tripathy, M.K., and Mitra, D. Mitochondrial Complex I activity is impaired during HIV-1-induced T cell apoptosis. Cell Death Differ. 12: 1417-1428, 2005.

1. Augustine T, Chaudhary P, Gupta K, Islam S, Ghosh P, Santra MK, Mitra D. Cyclin F/FBXO1 Interacts with HIV-1 Viral Infectivity Factor (Vif) and Restricts Progeny Virion Infectivity by Ubiquitination and Proteasomal Degradation of Vif Protein through SCF (cyclin F) E3 Ligase Machinery. J Biol Chem. 292:5349-5363, 2017.

2. Chaudhary P, Khan SZ, Rawat P, Augustine T, Raynes DA, Guerriero V, Mitra, D. HSP70 binding protein 1 (HspBP1) suppresses HIV-1 replication by inhibiting NF-κB mediated activation of viral gene expression. Nucleic Acids Res. 44:1613-1629, 2016.

3. Rawat P, Mitra D. Cellular heat shock factor 1 positively regulates human immunodeficiency virus-1 gene expression and replication by two distinct pathways. Nucleic Acids Res. 39:5879-5892, 2011.

4. Kumar, M. and Mitra D. Heat shock protein 40 is necessary for human immunodeficiency virus-1 Nef mediated enhancement of viral gene expression and replication. J. Biol. Chem. 280: 40041-40050, 2005

5. Ladha, J. S., Tripathy, M.K., and Mitra, D. Mitochondrial Complex I activity is impaired during HIV-1-induced T cell apoptosis. Cell Death Differ. 12: 1417-1428, 2005.

Complete Publications List

1. Kumar Kushwaha P, Saurabh Srivastava K, Kumari N, Kumar R, Mitra D, Sharon A. Synthesis and anti-HIV activity of a new isoxazole containing disubstituted 1,2,4-oxadiazoles analogs. Bioorg Med Chem.15;56:116612, 2022.
2. Iyer K, Chand K, Mitra A, Trivedi J, Mitra D. Diversity in heat shock protein families: functional implications in virus infection with a comprehensive insight of their role in the HIV-1 life cycle. Cell Stress Chaperones. 26(5):743-768. 2021.
3. Gupta A, Sabarinathan R, Bala P, Donipadi V, Vashisht D, Katika MR, Kandakatla M, Mitra D, Dalal A, Bashyam MD. A comprehensive profile of genomic variations in the SARS-CoV-2 isolates from the state of Telangana, India. J Gen Virol. Mar;102(3):001562, 2021.
4. Chand K, Iyer K, Mitra D. Comparative analysis of differential gene expression of HSP40 and HSP70 family isoforms during heat stress and HIV-1 infection in T-cells. Cell Stress Chaperones. 26:403-416. 2021.
5. Jayaprakash, NG., Singh, A., Vivek, R., Yadav, S., Pathak, S., Trivedi, J., Jayaraman, N., Nandi, D., Mitra, D., and Surolia, A. The barley lectin, Horcolin binds high mannose glycans in a multivalent fashion, enabling high affinity, specific inhibition of cellular HIV infection. J Biol Chem. 295:12111-12129, 2020.
6. Trivedi, J., Ghosh, P., and Mitra, D. N-p-Tosyl-L-phenylalanine chloromethyl ketone (TPCK) inhibits HIV-1 by suppressing the activity of viral protease. Biochem Biophys Res Commun. 527(1):167-172, 2020.
7. Agarwal, R., Trivedi, J., and Mitra, D. High yield production of recombinant cyanovirin-N (antiviral lectin) exhibiting significant anti-HIV activity, from a rationally selected Escherichia coli strain. Process Biochemistry. 2020, https://doi.org/10.1016/j.procbio.2020.03.011
8. Trivedi, J., Mahajan, D., Jaffe, RJ., Acharya, A., Mitra, D., and Byrareddy, SN. Recent Advances in the Development of Integrase Inhibitors for HIV Treatment. Curr HIV/AIDS Rep. 17: 63-75, 2020.
9. Trivedi, J., Alam, A., Joshi, S., Kumar, TP., Chippala, V., Mainkar, PS., Chandrasekhar, S., Chattopadhyay, S., and Mitra, D. A novel isothiocyanate derivative inhibits HIV-1 gene expression and replication by modulating the nuclear matrix associated protein SMAR1. Antiviral Research, 173: 104648, 2020.
10. Trivedi, J., Parveen, A., Rozy, F., Mitra, A., Bal, C., Mitra, D., and Sharon, A. Discovery of 2-isoxazol-3-yl-acetamide analogues as heat shock protein 90 (HSP90) inhibitors with significant anti-HIV activity. Eur J Med Chem. 183: 111699, 2019.
11. Trivedi, J., Tripathi, A., Chattopadhyay, D., and Mitra, D. Plant derived molecules in managing HIV infection. Chapter-11. New look to Phytomedicine: Advancements in Herbal Products as novel drug leads, MS Ahmad Khan, I Ahmad and D. Chattopadhay Eds (Elsevier), pp. 273-298, 2019.
12. Gawali R, Trivedi J, Bhansali S, Bhosale R, Sarkar D, and Mitra D. Design, synthesis, docking studies and biological screening of 2-thiazolyl substituted -2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazines as potent HIV-1 reverse transcriptase inhibitors. Eur J Med Chem. 157: 310-319, 2018.
13. Augustine T, Chaudhary P, Gupta K, Islam S, Ghosh P, Santra MK, Mitra D. Cyclin F/FBXO1 Interacts with HIV-1 Viral Infectivity Factor (Vif) and Restricts Progeny Virion Infectivity by Ubiquitination and Proteasomal Degradation of Vif Protein through SCF (cyclin F) E3 Ligase Machinery. J Biol Chem. 292:5349-5363, 2017.
14. Shrivastava S, Trivedi J, Mitra D. Gene expression profiling reveals Nef induced deregulation of lipid metabolism in HIV-1 infected T cells. Biochem Biophys Res Commun. 472:169-174, 2016.
15. Chaudhary P, Khan SZ, Rawat P, Augustine T, Raynes DA, Guerriero V, Mitra, D. HSP70 binding protein 1 (HspBP1) suppresses HIV-1 replication by inhibiting NF-κB mediated activation of viral gene expression. Nucleic Acids Res. 44:1613-1629, 2016.
16. Dhamija N, Choudhary D, Ladha JS, Pillai B, Mitra D. Tat predominantly associates with host promoter elements in HIV-1-infected T-cells - regulatory basis of transcriptional repression of c-Rel. FEBS J. 282:595-610, 2015.
17. Bag P, Ojha D, Mukherjee H, Halder UC, Mondal S, Biswas A, Sharon A, Van Kaer L, Chakrabarty S, Das G, Mitra D, Chattopadhyay D. A dihydro-pyrido-indole potently inhibits HSV-1 infection by interfering the viral immediate early transcriptional events. Antiviral Res.105:126-134, 2014.
18. Mohan T, Mitra D, Rao DN. Nasal delivery of PLG microparticle encapsulated defensin peptides adjuvanted gp41 antigen confers strong and long-lasting immunoprotective response against HIV-1. Immunol Res. 58:139-153, 2014.
19. Mohan T, Mitra D, Rao DN. Comparative In-Vitro Functional Analysis of Synthetic Defensins and Their Corresponding Peptide Variants Against HIV-1NL4.3, E. coli, S. aureus and P. aeruginosa. Int. J. Pept. Res. Ther.,19: 245-255, 2013.
20. Sarkar R, Mitra D and Chakrabarti S. HIV-1 gp120 Protein down regulates Nef induced IL-6 release in immature dentritic cells through interplay of DC-SIGN. PLoS One, 8: e59073, 2013.
21. Bhaskar C, Reddy PS, Chandra KS, Sabde S, Mitra D and Kondapi AK. Identification of the potential regions of Epap-1 that interacts with V3 loop of HIV-1 gp120. Biochim Biophys Acta. 1834:780-790, 2013.
22. Ahmed N, Brahmbhatt KG, Khan SI, Jacob M, Tekwani BL, Sabde S, Mitra D, Singh IP, Khan IA, Bhutani KK. Synthesis and Biological Evaluation of Tricyclic Guanidine Analogues of Batzelladine K for Antimalarial, Antileishmanial, Antibacterial, Antifungal, and Anti-HIV Activities. Chem Biol Drug Des. 81: 491-498, 2013.
23. Dhamija N, Rawat P and Mitra D. Epigenetic Regulation of HIV-1 Persistence and Evolving Strategies for Virus Eradication. Subcell Biochem. 61: 479-505, 2012.
24. Karampuri S, Bag P, Yasmin S, Chouhan DK, Bal C, Mitra D, Chattopadhyay D, Sharon A. Structure based molecular design, synthesis and biological evaluation of α-pyrone analogs as anti-HSV agent. Bioorg Med Chem Lett. 22: 6261-6266, 2012.
25. Sarkar R, Sarkar K, Brajachand Singh N, Manihar Singh Y, Mitra D, Chakrabarti S. Emergence of a unique recombinant form of HIV-1 from Manipur (India). J Clin Virol. 55: 274-277, 2012.
26. Kumar M, Rawat P, Khan SZ, Dhamija N, Chaudhary P, Ravi DS, Mitra D. Reciprocal regulation of human immunodeficiency virus-1 gene expression and replication by heat shock proteins 40 and 70. J Mol Biol. 410: 944- 958, 2011.
27. Khan SZ, Mitra D. Cyclin K inhibits HIV-1 gene expression and replication by interfering with CDK9-Cyclin T1 interaction in Nef dependent manner. J Biol Chem. 286: 22943- 22954, 2011.
28. Rawat P, Mitra D. Cellular heat shock factor 1 positively regulates human immunodeficiency virus-1 gene expression and replication by two distinct pathways. Nucleic Acids Res. 39:5879-5892, 2011.
29. Sabde S, Bodiwala HS, Karmase A, Deshpande PJ, Kaur A, Ahmed N, Chauthe SK, Brahmbhatt KG, Phadke RU, Mitra D, Bhutani KK, Singh IP. Anti-HIV activity of Indian medicinal plants. J Nat Med. 65: 662- 669, 2011.
30. Bodiwala HS, Sabde S, Mitra D, Bhutani KK, Singh IP. Synthesis of 9-substituted derivatives of berberine as anti-HIV agents. Eur J Med Chem. 46:1045-1049, 2011.
31. Bodiwala HS, Sabde S, Gupta P, Mukherjee R, Kumar R, Garg P, Bhutani KK, Mitra D, Singh IP. Design and synthesis of caffeoyl-anilides as portmanteau inhibitors of HIV-1 integrase and CCR5. Bioorg Med Chem. 19: 1256-1263, 2011.
32. Tripathy MK, Ahmed Z, Ladha JS, Mitra D. The cell death regulator GRIM-19 is involved in HIV-1 induced T-cell apoptosis. Apoptosis, 15:1453- 1460, 2010.
33. Brahmbhatt KG, Ahmed N, Sabde S, Mitra D, Singh IP, Bhutani KK. Synthesis and evaluation of beta-carboline derivatives as inhibitors of human immunodeficiency virus. Bioorg Med Chem Lett. 20: 4416-9, 2010.
34. Pawar V, Lokwani D, Bhandari S, Mitra D, Sabde S, Bothara K, Madgulkar A. Design of potential reverse transcriptase inhibitor containing Isatin nucleus using molecular modeling studies. Bioorg Med Chem. 18: 3198-3211, 2010.
35. Ahmed N, Brahmbhatt KG, Sabde S, Mitra D, Singh IP, Bhutani KK. Synthesis and anti-HIV activity of alkylated quinoline 2,4-diols. Bioorg Med Chem. 18: 2872-2879, 2010.
36. Sreenath K, Pavithra L, Singh S, Sinha S, Dash PK, Siddappa NB, Ranga U, Mitra D, Chattopadhyay S. Nuclear matrix protein SMAR1 represses HIV-1 LTR mediated transcription through chromatin remodelling. Virology. 400: 76-85, 2010.
37. Chauthe SK, Bharate SB, Sabde S, Mitra D, Bhutani KK, Singh IP. Biomimetic synthesis and anti-HIV activity of dimeric phloroglucinols. Bioorg Med Chem. 18: 2029-2036, 2010.
38. Ranga UK, Banerjea A, Chakrabarti S and Mitra D. HIV/AIDS research in India: past, present and future. Curr. Sci. 98: 335-345, 2010.
39. Tripathy MK, Mitra D. Differential modulation of mitochondrial OXPHOS system during HIV-1 induced T-cell apoptosis: up regulation of Complex-IV subunit COX-II and its possible implications Apoptosis 15: 28 – 40, 2010.
40. Bodiwala HS, Sabde S, Mitra D, Bhutani KK, Singh IP. Anti-HIV diterpenes from Coleus forskohlii. Nat Prod Commun. 4: 1173-1175, 2009.
41. Pal D, Chakraborty P, Ray HN, Pal BC, Mitra D, Kabir SN. Acaciaside-B-enriched fraction of Acacia auriculiformis is a prospective spermicide with no mutagenic property. Reproduction. 138: 453- 462, 2009.
42. Ahluwalia JK, Khan SZ, Soni K, Rawat P, Gupta A, Hariharan M, Scaria V, Lalwani M, Pillai B, Mitra D, Brahmachari SK. Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication. Retrovirology. 23: 117, 2008.
43. Talwar GP, Dar SA, Rai MK, Reddy KV, Mitra D, Kulkarni SV, Doncel GF, Buck CB, Schiller JT, Muralidhar S, Bala M, Agrawal SS, Bansal K, Verma JK. A novel polyherbal microbicide with inhibitory effect on bacterial, fungal and viral genital pathogens. Int J Antimicrob Agents. 32: 180- 185, 2008.
44. Gupta S, Boppana R, Mishra GC, Saha B, Mitra D. Interleukin-12 is necessary for the priming of CD4(+) T cells required during the elicitation of HIV-1 gp120-specific cytotoxic T-lymphocyte function. Immunology. 124: 553- 561, 2008.
45. Purbey PK, Singh S, Kumar PP, Mehta S, Ganesh KN, Mitra D, Galande S. PDZ domain-mediated dimerization and homeodomain-directed specificity are required for high-affinity DNA binding by SATB1. Nucleic Acids Res. 36: 2107 – 2122, 2008.
46. Gupta, S., Boppana, R., Mishra, G.C., Saha, B. and Mitra, D. HIV-1 Tat Suppresses gp120- Specific T Cell Response in IL-10-Dependent Manner. J. Immunol. 180: 79-88, 2008.
47. Gupta S, Mitra D. Human immunodeficiency virus-1 Tat protein: immunological facets of a transcriptional activator. Indian J Biochem Biophys. 44: 269 – 275, 2007.
48. Mitra, D. Marine organisms as a source of anti-HIV activity. In: Sir Dorabji Tata Symposium Series: Research Issues in HIV/AIDS. D. Raghunath and C. Durga Rao (Eds). Vol. 7, pp 374 – 383, Tata McGraw-Hill, India, 2007.
49. Kumar, P. P., Mehta, S., Purbey, P. K., Notani. D., Jayani, R. S., Purohit, H. J., Raje, D. V., Ravi, D. S., Bhonde, R. R., Mitra, D. and Galande, S. SATB1-binding sequences and Alu-like motifs define a unique chromatin context in the vicinity of HIV-1 integration sites. J Virol. 81: 5617 – 5627, 2007.
50. Murugaiyan, G., Agrawal, R., Mishra, G. C., Mitra, D. and Saha, B. Differential CD40/CD40L expression results in counteracting antitumor immune responses. J Immunol. 178: 2047-2055, 2007.
51. Ravi, D. S. and Mitra, D. HIV-1 long terminal repeat promoter regulated dual reporter: potential use in screening of transcription modulators. Anal Biochem. 360: 315-317, 2007.
52. Murugaiyan, G., Agrawal, R., Mishra, G. C., Mitra, D. and Saha B. Functional dichotomy in CD40 reciprocally regulates effector T cell functions. J Immunol. 177: 6642-6649, 2006.
53. Bodas, M., Jain, N., Awasthi, A., Martin, S., Penke Loka, R.K., Dandekar, D., Mitra, D. and Saha B. Inhibition of IL-2 induced IL-10 production as a principle of phase-specific immunotherapy. J Immunol. 177: 4636- 4643, 2006.
54. Salunke, D. B., Ravi, D. S., Pore, V. S., Mitra, D. and Hazra, B. G. Amino functionalized novel cholic acid derivatives induce HIV-1 replication and syncytia formation in T cells. J Med Chem. 49: 2652-2655, 2006.
55. Kumar, M. and Mitra D. Heat shock protein 40 is necessary for human immunodeficiency virus-1 Nef mediated enhancement of viral gene expression and replication. J. Biol. Chem. 280: 40041-40050, 2005
56. Ladha, J. S., Tripathy, M.K., and Mitra, D. Mitochondrial Complex I activity is impaired during HIV-1-induced T cell apoptosis. Cell Death Differ. 12: 1417-1428, 2005.
57. Dandekar, D. H., Kumar, M., Ladha, J. S., Ganesh, K. N. and Mitra, D. A quantitative method for normalization of transfection efficiency using enhanced green fluorescent protein. Anal. Biochem. 342: 341-344, 2005.
58. Kulkarni, A., Ravi, D. S., Singh, K., Rampalli, S., Parekh, V., Mitra, D., and Chattopadhyay, S. HIV-1 Tat modulates T-bet expression and induces Th1 type of immune response. Biochem Biophys Res Commun. 329:706-712, 2005.
59. Kumar, P. P., Purbey, P. K., Ravi, D. S., Mitra, D., and Galande, S. Displacement of SATB1-bound histone deacetylase 1 corepressor by the human immunodeficiency virus type 1 transactivator induces expression of interleukin-2 and its receptor in T cells. Mol Cell Biol. 25:1620-1633, 2005.
60. Joseph, A. M., Kumar, M., and Mitra, D. Nef: "necessary and enforcing factor" in HIV infection. Curr. HIV Res. 3:87-94, 2005.
61. Dandekar, D.H., Ganesh, K.N., and Mitra, D. HIV-1 Tat directly binds to NFkB enhancer sequence: role in viral and cellular gene expression. Nucleic Acids Res. 32: 1270-1278, 2004.
62. Joseph, A. M., Ladha, J.S., Mojamdar, M., and Mitra, D. Human Immunodeficiency virus-1 Nef protein interacts with Tat and enhances HIV-1 gene expression. FEBS Lett. 548: 37-42, 2003.
63. Rampalli, S., Kulkarni, A., Kumar, P. P., Mogare, D., Galande, S., Mitra, D., and Chattopadhyay, S. Stimulation of Tat independent transcriptional processivity from the HIV-1 LTR promoter by Matrix Attachment Regions. Nucleic Acids Res. 31: 3248-3256, 2003.
64. Awasthi, A., Mathur, R., Khan A., Joshi, B.N., Jain, N., Sawant, S., Ramanmurthy, B., Mitra, D. and Saha B. CD40 Signaling Is Impaired in L. major –infected Macrophages and Is Rescued by a p38MAPK Activator establishing a Host-protective Memory T Cell Response. J. Exp.Med. 197: 1037-1043, 2003.
65. Banerjee PP, Vinay DS, Mathew A, Raje M, Parekh V, Prasad DV, Kumar A, Mitra D, Mishra GC. Evidence that glycoprotein 96 (B2), a stress protein, functions as a Th2-specific costimulatory molecule. J. Immunol. 169: 3507-3518, 2002.
66. Venuprasad, K., Banerjee, P. P., Chattopadhyay, S., Sharma, S., Pal, S., Parab, P. B., Mitra, D., and Saha, B. Human neutrophil-expressed CD28 interacts with macrophage B7 to induce phosphatidylinositol 3-kinase-dependent IFN-gamma secretion and restriction of Leishmania growth. J. Immunol. 169: 920-928, 2002.
67. Deshpande, M., Venuprasad, K., Parab, P.B., Saha, B. and Mitra, D. A novel CD28 mRNA variant and simultaneous presence of various CD28 mRNA isoforms in human T lymphocytes. Human Immunology. 63: 20-23, 2002.
68. Venuprasad, K., Parab, P., Prasad, D.V.R., Sharma, S., Bannerjee, P.P., Deshpande, M., Mitra, D.K., Pal, S., Bhadra, R., Mitra, D., and Saha, B. Immunobiology of CD28 expression on human neutrophils. I. CD28 regulates neutrophil migration by modulating CXCR-1 expression. Eur. J. Immunol. 31: 1536-1543, 2001.
69. Deshpande, M., Mitra, D., and Parab, P. B. Polyacrylamide gel as a matrix for the delivery of a layer or coat of other molecules. Biotechniques, 30: 258-262, 2001.

1. Kumar Kushwaha P, Saurabh Srivastava K, Kumari N, Kumar R, Mitra D, Sharon A. Synthesis and anti-HIV activity of a new isoxazole containing disubstituted 1,2,4-oxadiazoles analogs. Bioorg Med Chem.15;56:116612, 2022.

2. Iyer K, Chand K, Mitra A, Trivedi J, Mitra D. Diversity in heat shock protein families: functional implications in virus infection with a comprehensive insight of their role in the HIV-1 life cycle. Cell Stress Chaperones. 26(5):743-768. 2021.

3. Gupta A, Sabarinathan R, Bala P, Donipadi V, Vashisht D, Katika MR, Kandakatla M, Mitra D, Dalal A, Bashyam MD. A comprehensive profile of genomic variations in the SARS-CoV-2 isolates from the state of Telangana, India. J Gen Virol. Mar;102(3):001562, 2021.

4. Chand K, Iyer K, Mitra D. Comparative analysis of differential gene expression of HSP40 and HSP70 family isoforms during heat stress and HIV-1 infection in T-cells. Cell Stress Chaperones. 26:403-416. 2021.

5. Jayaprakash, NG., Singh, A., Vivek, R., Yadav, S., Pathak, S., Trivedi, J., Jayaraman, N., Nandi, D., Mitra, D., and Surolia, A. The barley lectin, Horcolin binds high mannose glycans in a multivalent fashion, enabling high affinity, specific inhibition of cellular HIV infection. J Biol Chem. 295:12111-12129, 2020.

6. Trivedi, J., Ghosh, P., and Mitra, D. N-p-Tosyl-L-phenylalanine chloromethyl ketone (TPCK) inhibits HIV-1 by suppressing the activity of viral protease. Biochem Biophys Res Commun. 527(1):167-172, 2020.

7. Agarwal, R., Trivedi, J., and Mitra, D. High yield production of recombinant cyanovirin-N (antiviral lectin) exhibiting significant anti-HIV activity, from a rationally selected Escherichia coli strain. Process Biochemistry. 2020, https://doi.org/10.1016/j.procbio.2020.03.011

8. Trivedi, J., Mahajan, D., Jaffe, RJ., Acharya, A., Mitra, D., and Byrareddy, SN. Recent Advances in the Development of Integrase Inhibitors for HIV Treatment. Curr HIV/AIDS Rep. 17: 63-75, 2020.

9. Trivedi, J., Alam, A., Joshi, S., Kumar, TP., Chippala, V., Mainkar, PS., Chandrasekhar, S., Chattopadhyay, S., and Mitra, D. A novel isothiocyanate derivative inhibits HIV-1 gene expression and replication by modulating the nuclear matrix associated protein SMAR1. Antiviral Research, 173: 104648, 2020.

10. Trivedi, J., Parveen, A., Rozy, F., Mitra, A., Bal, C., Mitra, D., and Sharon, A. Discovery of 2-isoxazol-3-yl-acetamide analogues as heat shock protein 90 (HSP90) inhibitors with significant anti-HIV activity. Eur J Med Chem. 183: 111699, 2019.

11. Trivedi, J., Tripathi, A., Chattopadhyay, D., and Mitra, D. Plant derived molecules in managing HIV infection. Chapter-11. New look to Phytomedicine: Advancements in Herbal Products as novel drug leads, MS Ahmad Khan, I Ahmad and D. Chattopadhay Eds (Elsevier), pp. 273-298, 2019.

12. Gawali R, Trivedi J, Bhansali S, Bhosale R, Sarkar D, and Mitra D. Design, synthesis, docking studies and biological screening of 2-thiazolyl substituted -2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazines as potent HIV-1 reverse transcriptase inhibitors. Eur J Med Chem. 157: 310-319, 2018.

13. Augustine T, Chaudhary P, Gupta K, Islam S, Ghosh P, Santra MK, Mitra D. Cyclin F/FBXO1 Interacts with HIV-1 Viral Infectivity Factor (Vif) and Restricts Progeny Virion Infectivity by Ubiquitination and Proteasomal Degradation of Vif Protein through SCF (cyclin F) E3 Ligase Machinery. J Biol Chem. 292:5349-5363, 2017.

14. Shrivastava S, Trivedi J, Mitra D. Gene expression profiling reveals Nef induced deregulation of lipid metabolism in HIV-1 infected T cells. Biochem Biophys Res Commun. 472:169-174, 2016.

15. Chaudhary P, Khan SZ, Rawat P, Augustine T, Raynes DA, Guerriero V, Mitra, D. HSP70 binding protein 1 (HspBP1) suppresses HIV-1 replication by inhibiting NF-κB mediated activation of viral gene expression. Nucleic Acids Res. 44:1613-1629, 2016.

16. Dhamija N, Choudhary D, Ladha JS, Pillai B, Mitra D. Tat predominantly associates with host promoter elements in HIV-1-infected T-cells - regulatory basis of transcriptional repression of c-Rel. FEBS J. 282:595-610, 2015.

17. Bag P, Ojha D, Mukherjee H, Halder UC, Mondal S, Biswas A, Sharon A, Van Kaer L, Chakrabarty S, Das G, Mitra D, Chattopadhyay D. A dihydro-pyrido-indole potently inhibits HSV-1 infection by interfering the viral immediate early transcriptional events. Antiviral Res.105:126-134, 2014.

18. Mohan T, Mitra D, Rao DN. Nasal delivery of PLG microparticle encapsulated defensin peptides adjuvanted gp41 antigen confers strong and long-lasting immunoprotective response against HIV-1. Immunol Res. 58:139-153, 2014.

19. Mohan T, Mitra D, Rao DN. Comparative In-Vitro Functional Analysis of Synthetic Defensins and Their Corresponding Peptide Variants Against HIV-1NL4.3, E. coli, S. aureus and P. aeruginosa. Int. J. Pept. Res. Ther.,19: 245-255, 2013.

20. Sarkar R, Mitra D and Chakrabarti S. HIV-1 gp120 Protein down regulates Nef induced IL-6 release in immature dentritic cells through interplay of DC-SIGN. PLoS One, 8: e59073, 2013.

21. Bhaskar C, Reddy PS, Chandra KS, Sabde S, Mitra D and Kondapi AK. Identification of the potential regions of Epap-1 that interacts with V3 loop of HIV-1 gp120. Biochim Biophys Acta. 1834:780-790, 2013.

22. Ahmed N, Brahmbhatt KG, Khan SI, Jacob M, Tekwani BL, Sabde S, Mitra D, Singh IP, Khan IA, Bhutani KK. Synthesis and Biological Evaluation of Tricyclic Guanidine Analogues of Batzelladine K for Antimalarial, Antileishmanial, Antibacterial, Antifungal, and Anti-HIV Activities. Chem Biol Drug Des. 81: 491-498, 2013.

23. Dhamija N, Rawat P and Mitra D. Epigenetic Regulation of HIV-1 Persistence and Evolving Strategies for Virus Eradication. Subcell Biochem. 61: 479-505, 2012.

24. Karampuri S, Bag P, Yasmin S, Chouhan DK, Bal C, Mitra D, Chattopadhyay D, Sharon A. Structure based molecular design, synthesis and biological evaluation of α-pyrone analogs as anti-HSV agent. Bioorg Med Chem Lett. 22: 6261-6266, 2012.

25. Sarkar R, Sarkar K, Brajachand Singh N, Manihar Singh Y, Mitra D, Chakrabarti S. Emergence of a unique recombinant form of HIV-1 from Manipur (India). J Clin Virol. 55: 274-277, 2012.

26. Kumar M, Rawat P, Khan SZ, Dhamija N, Chaudhary P, Ravi DS, Mitra D. Reciprocal regulation of human immunodeficiency virus-1 gene expression and replication by heat shock proteins 40 and 70. J Mol Biol. 410: 944- 958, 2011.

27. Khan SZ, Mitra D. Cyclin K inhibits HIV-1 gene expression and replication by interfering with CDK9-Cyclin T1 interaction in Nef dependent manner. J Biol Chem. 286: 22943- 22954, 2011.

28. Rawat P, Mitra D. Cellular heat shock factor 1 positively regulates human immunodeficiency virus-1 gene expression and replication by two distinct pathways. Nucleic Acids Res. 39:5879-5892, 2011.

29. Sabde S, Bodiwala HS, Karmase A, Deshpande PJ, Kaur A, Ahmed N, Chauthe SK, Brahmbhatt KG, Phadke RU, Mitra D, Bhutani KK, Singh IP. Anti-HIV activity of Indian medicinal plants. J Nat Med. 65: 662- 669, 2011.

30. Bodiwala HS, Sabde S, Mitra D, Bhutani KK, Singh IP. Synthesis of 9-substituted derivatives of berberine as anti-HIV agents. Eur J Med Chem. 46:1045-1049, 2011.

31. Bodiwala HS, Sabde S, Gupta P, Mukherjee R, Kumar R, Garg P, Bhutani KK, Mitra D, Singh IP. Design and synthesis of caffeoyl-anilides as portmanteau inhibitors of HIV-1 integrase and CCR5. Bioorg Med Chem. 19: 1256-1263, 2011.

32. Tripathy MK, Ahmed Z, Ladha JS, Mitra D. The cell death regulator GRIM-19 is involved in HIV-1 induced T-cell apoptosis. Apoptosis, 15:1453- 1460, 2010.

33. Brahmbhatt KG, Ahmed N, Sabde S, Mitra D, Singh IP, Bhutani KK. Synthesis and evaluation of beta-carboline derivatives as inhibitors of human immunodeficiency virus. Bioorg Med Chem Lett. 20: 4416-9, 2010.

34. Pawar V, Lokwani D, Bhandari S, Mitra D, Sabde S, Bothara K, Madgulkar A. Design of potential reverse transcriptase inhibitor containing Isatin nucleus using molecular modeling studies. Bioorg Med Chem. 18: 3198-3211, 2010.

35. Ahmed N, Brahmbhatt KG, Sabde S, Mitra D, Singh IP, Bhutani KK. Synthesis and anti-HIV activity of alkylated quinoline 2,4-diols. Bioorg Med Chem. 18: 2872-2879, 2010.

36. Sreenath K, Pavithra L, Singh S, Sinha S, Dash PK, Siddappa NB, Ranga U, Mitra D, Chattopadhyay S. Nuclear matrix protein SMAR1 represses HIV-1 LTR mediated transcription through chromatin remodelling. Virology. 400: 76-85, 2010.

37. Chauthe SK, Bharate SB, Sabde S, Mitra D, Bhutani KK, Singh IP. Biomimetic synthesis and anti-HIV activity of dimeric phloroglucinols. Bioorg Med Chem. 18: 2029-2036, 2010.

38. Ranga UK, Banerjea A, Chakrabarti S and Mitra D. HIV/AIDS research in India: past, present and future. Curr. Sci. 98: 335-345, 2010.

39. Tripathy MK, Mitra D. Differential modulation of mitochondrial OXPHOS system during HIV-1 induced T-cell apoptosis: up regulation of Complex-IV subunit COX-II and its possible implications Apoptosis 15: 28 – 40, 2010.

40. Bodiwala HS, Sabde S, Mitra D, Bhutani KK, Singh IP. Anti-HIV diterpenes from Coleus forskohlii. Nat Prod Commun. 4: 1173-1175, 2009.

41. Pal D, Chakraborty P, Ray HN, Pal BC, Mitra D, Kabir SN. Acaciaside-B-enriched fraction of Acacia auriculiformis is a prospective spermicide with no mutagenic property. Reproduction. 138: 453- 462, 2009.

42. Ahluwalia JK, Khan SZ, Soni K, Rawat P, Gupta A, Hariharan M, Scaria V, Lalwani M, Pillai B, Mitra D, Brahmachari SK. Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication. Retrovirology. 23: 117, 2008.

43. Talwar GP, Dar SA, Rai MK, Reddy KV, Mitra D, Kulkarni SV, Doncel GF, Buck CB, Schiller JT, Muralidhar S, Bala M, Agrawal SS, Bansal K, Verma JK. A novel polyherbal microbicide with inhibitory effect on bacterial, fungal and viral genital pathogens. Int J Antimicrob Agents. 32: 180- 185, 2008.

44. Gupta S, Boppana R, Mishra GC, Saha B, Mitra D. Interleukin-12 is necessary for the priming of CD4(+) T cells required during the elicitation of HIV-1 gp120-specific cytotoxic T-lymphocyte function. Immunology. 124: 553- 561, 2008.

45. Purbey PK, Singh S, Kumar PP, Mehta S, Ganesh KN, Mitra D, Galande S. PDZ domain-mediated dimerization and homeodomain-directed specificity are required for high-affinity DNA binding by SATB1. Nucleic Acids Res. 36: 2107 – 2122, 2008.

46. Gupta, S., Boppana, R., Mishra, G.C., Saha, B. and Mitra, D. HIV-1 Tat Suppresses gp120- Specific T Cell Response in IL-10-Dependent Manner. J. Immunol. 180: 79-88, 2008.

47. Gupta S, Mitra D. Human immunodeficiency virus-1 Tat protein: immunological facets of a transcriptional activator. Indian J Biochem Biophys. 44: 269 – 275, 2007.

48. Mitra, D. Marine organisms as a source of anti-HIV activity. In: Sir Dorabji Tata Symposium Series: Research Issues in HIV/AIDS. D. Raghunath and C. Durga Rao (Eds). Vol. 7, pp 374 – 383, Tata McGraw-Hill, India, 2007.

49. Kumar, P. P., Mehta, S., Purbey, P. K., Notani. D., Jayani, R. S., Purohit, H. J., Raje, D. V., Ravi, D. S., Bhonde, R. R., Mitra, D. and Galande, S. SATB1-binding sequences and Alu-like motifs define a unique chromatin context in the vicinity of HIV-1 integration sites. J Virol. 81: 5617 – 5627, 2007.

50. Murugaiyan, G., Agrawal, R., Mishra, G. C., Mitra, D. and Saha, B. Differential CD40/CD40L expression results in counteracting antitumor immune responses. J Immunol. 178: 2047-2055, 2007.

51. Ravi, D. S. and Mitra, D. HIV-1 long terminal repeat promoter regulated dual reporter: potential use in screening of transcription modulators. Anal Biochem. 360: 315-317, 2007.

52. Murugaiyan, G., Agrawal, R., Mishra, G. C., Mitra, D. and Saha B. Functional dichotomy in CD40 reciprocally regulates effector T cell functions. J Immunol. 177: 6642-6649, 2006.

53. Bodas, M., Jain, N., Awasthi, A., Martin, S., Penke Loka, R.K., Dandekar, D., Mitra, D. and Saha B. Inhibition of IL-2 induced IL-10 production as a principle of phase-specific immunotherapy. J Immunol. 177: 4636- 4643, 2006.

54. Salunke, D. B., Ravi, D. S., Pore, V. S., Mitra, D. and Hazra, B. G. Amino functionalized novel cholic acid derivatives induce HIV-1 replication and syncytia formation in T cells. J Med Chem. 49: 2652-2655, 2006.

55. Kumar, M. and Mitra D. Heat shock protein 40 is necessary for human immunodeficiency virus-1 Nef mediated enhancement of viral gene expression and replication. J. Biol. Chem. 280: 40041-40050, 2005

56. Ladha, J. S., Tripathy, M.K., and Mitra, D. Mitochondrial Complex I activity is impaired during HIV-1-induced T cell apoptosis. Cell Death Differ. 12: 1417-1428, 2005.

57. Dandekar, D. H., Kumar, M., Ladha, J. S., Ganesh, K. N. and Mitra, D. A quantitative method for normalization of transfection efficiency using enhanced green fluorescent protein. Anal. Biochem. 342: 341-344, 2005.

58. Kulkarni, A., Ravi, D. S., Singh, K., Rampalli, S., Parekh, V., Mitra, D., and Chattopadhyay, S. HIV-1 Tat modulates T-bet expression and induces Th1 type of immune response. Biochem Biophys Res Commun. 329:706-712, 2005.

59. Kumar, P. P., Purbey, P. K., Ravi, D. S., Mitra, D., and Galande, S. Displacement of SATB1-bound histone deacetylase 1 corepressor by the human immunodeficiency virus type 1 transactivator induces expression of interleukin-2 and its receptor in T cells. Mol Cell Biol. 25:1620-1633, 2005.

60. Joseph, A. M., Kumar, M., and Mitra, D. Nef: "necessary and enforcing factor" in HIV infection. Curr. HIV Res. 3:87-94, 2005.

61. Dandekar, D.H., Ganesh, K.N., and Mitra, D. HIV-1 Tat directly binds to NFkB enhancer sequence: role in viral and cellular gene expression. Nucleic Acids Res. 32: 1270-1278, 2004.

62. Joseph, A. M., Ladha, J.S., Mojamdar, M., and Mitra, D. Human Immunodeficiency virus-1 Nef protein interacts with Tat and enhances HIV-1 gene expression. FEBS Lett. 548: 37-42, 2003.

63. Rampalli, S., Kulkarni, A., Kumar, P. P., Mogare, D., Galande, S., Mitra, D., and Chattopadhyay, S. Stimulation of Tat independent transcriptional processivity from the HIV-1 LTR promoter by Matrix Attachment Regions. Nucleic Acids Res. 31: 3248-3256, 2003.

64. Awasthi, A., Mathur, R., Khan A., Joshi, B.N., Jain, N., Sawant, S., Ramanmurthy, B., Mitra, D. and Saha B. CD40 Signaling Is Impaired in L. major –infected Macrophages and Is Rescued by a p38MAPK Activator establishing a Host-protective Memory T Cell Response. J. Exp.Med. 197: 1037-1043, 2003.

65. Banerjee PP, Vinay DS, Mathew A, Raje M, Parekh V, Prasad DV, Kumar A, Mitra D, Mishra GC. Evidence that glycoprotein 96 (B2), a stress protein, functions as a Th2-specific costimulatory molecule. J. Immunol. 169: 3507-3518, 2002.

66. Venuprasad, K., Banerjee, P. P., Chattopadhyay, S., Sharma, S., Pal, S., Parab, P. B., Mitra, D., and Saha, B. Human neutrophil-expressed CD28 interacts with macrophage B7 to induce phosphatidylinositol 3-kinase-dependent IFN-gamma secretion and restriction of Leishmania growth. J. Immunol. 169: 920-928, 2002.

67. Deshpande, M., Venuprasad, K., Parab, P.B., Saha, B. and Mitra, D. A novel CD28 mRNA variant and simultaneous presence of various CD28 mRNA isoforms in human T lymphocytes. Human Immunology. 63: 20-23, 2002.

68. Venuprasad, K., Parab, P., Prasad, D.V.R., Sharma, S., Bannerjee, P.P., Deshpande, M., Mitra, D.K., Pal, S., Bhadra, R., Mitra, D., and Saha, B. Immunobiology of CD28 expression on human neutrophils. I. CD28 regulates neutrophil migration by modulating CXCR-1 expression. Eur. J. Immunol. 31: 1536-1543, 2001.

69. Deshpande, M., Mitra, D., and Parab, P. B. Polyacrylamide gel as a matrix for the delivery of a layer or coat of other molecules. Biotechniques, 30: 258-262, 2001.

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Last updated On : 08 July 2022 04:57