Scientist Profile

Bhaskar Saha, Ph.D.

Immuno-parasitology; Cancer biology; Cell signaling
Email

sahab@nccs.res.in

Research Areas

Pathogenesis and Cellular Response

Current Designation

Scientist 'G', National Centre for Cell Science

Research Projects

  1. Leishmania-macrophage interaction
  2. CD40 signaling
  3. DC subset mediated priming against prostate cancer
  4. Development and regulation of regulatory T cells in leishmaniasis
  5. DC subsets in leishmaniasis and regulation of T cell response 

Publications

K Venuprasad, Pinaki Banerjee, Satyan Sharma, Subrata Pal, PB Parab,D Mitra, Bhaskar Saha. 2002. Human neutrophil expressed CD28 interacts with macrophage expressed B7 to induce IFN-g and restrict Leishmania growth. J. Immunol. 169: 920-928.

Amit Awasthi, Ramkumar Mathur, AA Khan, Bimba Joshi, Nitya Jain, Sangeeta Sawant, Debashis Mitra and Bhaskar Saha. 2003. CD40 signaling is impaired in L. major-infected macrophages and is rescued by a p38MAPK activator establishing a host-protective memory T cell response. J. Exp. Med. 197:1037-1043.

Amit Ashtekar and Bhaskar Saha. 2003. Poly,s plea: membership to the club of APCs. Trends in Immunol. 24: 485-490.

Mathur RK, Awasthi A, Wadhone P, Ramanamurthy B, Saha B. Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses. Nat Med. 2004 May;10(5):540-4. Epub 2004 Apr 25

Mathur RK, Awasthi A, Saha B. The conundrum of CD40 function: host protection or disease promotion? Trends Parasitol. 2006 Mar;22(3):117-22.

Murugaiyan G, Agrawal R, Mishra GC, Mitra D, Saha B. Functional dichotomy in CD40 reciprocally regulates effector T cell functions. J Immunol. 2006 Nov 15;177(10):6642-9.

Murugaiyan G, Agrawal R, Mishra GC, Mitra D, Saha B. Differential CD40/CD40L expression results in counteracting antitumor immune responses. J Immunol. 2007 Feb 15;178(4):2047-55.

Murugaiyan G, Martin S, Saha B. CD40-induced countercurrent conduits for tumor escape or elimination?Trends Immunol. 2007 Nov;28(11):467-73. Epub 2007 Nov 5.

Rub A, Dey R, Jadhav M, Kamat R, Chakkaramakkil S, Majumdar S, Mukhopadhyaya R, Saha B. Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function. Nat Immunol. 2009 Mar;10(3):273-80.

Murugaiyan G, Saha B. Protumor vs antitumor functions of IL-17. J Immunol. 2009 Oct 1;183(7):4169-75.

Martin S, Pahari S, Sudan R, Saha B. CD40 signaling in CD8+CD40+ T cells turns on contra-T regulatory cell functions. J Immunol. 2010 May 15;184(10):5510-8.

Martin S, Agarwal R, Murugaiyan G, Saha B. CD40 expression levels modulate regulatory T cells in Leishmania donovani infection. J Immunol. 2010 Jul 1;185(1):551-9. 

 

  • Molecular Immunology Forum
  • Society of Biological Chemists (India)
  • Indian Immunology Society

Teaching

  • M.Sc. Biotechnology, Pune University, Maharashtra.
  • M.Sc. Physiology, Vidyasagar University, West Bengal. 

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